Du Dengkui, Jing Zhaopu, Zhang Guangyang, Dang Xiaoqian, Liu Ruiyu, Song Jidong
Department of Orthopaedics, The Second Affiliated Hospital, Xi'an Jiaotong University, No.157, Xiwu Road, Xi'an, 710004, Shaanxi Province, China.
Department of Orthopaedics, Luoyang Central Hospital, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, 471009, Henan Province, China.
Diabetol Metab Syndr. 2022 May 3;14(1):63. doi: 10.1186/s13098-022-00840-x.
The relationship between obesity and osteoporosis is an important public health issue. The goal of this study was to investigate whether and to what extent central obesity traits affect bone mineral density (BMD).
We conducted a two-sample Mendelian randomization analysis. Genomewide significant single nucleotide polymorphisms associated with waist circumference, hip circumference, waist-to-hip ratio, waist circumference adjusted by body mass index (WCadjBMI), hip circumference adjusted by BMI (HCadjBMI) and waist-to-hip ratio adjusted by BMI (WHRadjBMI) were obtained from a large-scale database containing 224,459 samples. The BMD summary dataset was obtained from a UK Biobank database including 265,627 participants.
The results provided strong evidence that the HCadjBMI trait was causally and negatively associated with BMD (β: - 0.135, 95% CI - 0.216 to - 0.054; P = 0.001), while the WHR trait was causally and positively associated with BMD (β: 0.194, 95% CI 0.062 to 0.325, P = 0.004). No significant effects were observed for other traits on BMD.
This study indicates variations in the abilities of different central obesity traits to influence BMD. These results should be considered in further studies and public health measures on obesity and osteoporosis prevention strategies.
肥胖与骨质疏松症之间的关系是一个重要的公共卫生问题。本研究的目的是调查中心性肥胖特征是否以及在多大程度上影响骨密度（BMD）。
我们进行了一项两样本孟德尔随机化分析。从一个包含224,459个样本的大规模数据库中获取与腰围、臀围、腰臀比、体重指数调整后的腰围（WCadjBMI）、体重指数调整后的臀围（HCadjBMI）和体重指数调整后的腰臀比（WHRadjBMI）相关的全基因组显著单核苷酸多态性。骨密度汇总数据集来自一个包含265,627名参与者的英国生物银行数据库。
结果提供了强有力的证据，表明HCadjBMI特征与骨密度存在因果负相关（β：-0.135，95%可信区间-0.216至-0.054；P = 0.001），而腰臀比特征与骨密度存在因果正相关（β：0.194，95%可信区间0.062至0.325，P = 0.004）。未观察到其他特征对骨密度有显著影响。
本研究表明不同中心性肥胖特征影响骨密度的能力存在差异。在进一步研究以及关于肥胖和骨质疏松预防策略的公共卫生措施中应考虑这些结果。
