Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
BMC Public Health. 2020 Mar 4;20(1):285. doi: 10.1186/s12889-020-8379-4.
Adiposity plays a crucial role in the risk of osteoporosis. However, the impact of body fat distribution on the skeleton is contentious. The study was designed to explore the association of various adiposity indices with estimated bone mineral density (BMD) and the risk of osteoporosis based on body mass index (BMI), body fat percentage (BFP), waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), and visceral fat index (VFI).
A total of 8475 subjects derived from the Henan Rural Cohort Study were analyzed. The estimated BMD of study participants were measured by calcaneal quantitative ultrasound (QUS). Linear regression and binary logistic regression were performed to estimate the association of adiposity and the outcomes.
The mean age of the study participants was 55.23 ± 11.09 years and 59.61% were women. The crude and age-standardized prevalence of high osteoporosis risk was 16.24 and 11.82%. Per unit increment in adiposity indices was associated with 0.005-0.021 g/cm increase in estimated BMD. The adjusted odds ratios (95% confidence interval) for high osteoporosis risk in per 1 SD increase of WC, WHR, WHtR, BMI, BFP, and VFI were 0.820 (0.748, 0.898), 0.872 (0.811, 0.938), 0.825 (0.765, 0.891), 0.798 (0.726, 0.878), 0.882 (0.800, 0.972), and 0.807 (0.732, 0.889), respectively. Stratified analyses indicated greater effects on individuals aged 55 years or older.
The adiposity indices have an inverse association with the risk of osteoporosis among Chinese rural population, especially in the elderly.
肥胖在骨质疏松风险中起着至关重要的作用。然而，体脂分布对骨骼的影响存在争议。本研究旨在探讨基于体重指数（BMI）、体脂百分比（BFP）、腰围（WC）、腰臀比（WHR）、腰高比（WHtR）和内脏脂肪指数（VFI）的各种肥胖指数与估计骨密度（BMD）和骨质疏松症风险的相关性。
对河南农村队列研究中的 8475 名受试者进行了分析。通过跟骨定量超声（QUS）测量研究参与者的估计 BMD。采用线性回归和二元逻辑回归来估计肥胖与结果的相关性。
研究参与者的平均年龄为 55.23±11.09 岁，59.61%为女性。高骨质疏松风险的粗患病率和年龄标准化患病率分别为 16.24%和 11.82%。每单位肥胖指数的增加与估计 BMD 增加 0.005-0.021 g/cm 相关。WC、WHR、WHtR、BMI、BFP 和 VFI 每增加 1 SD，高骨质疏松风险的调整后比值比（95%置信区间）分别为 0.820（0.748，0.898）、0.872（0.811，0.938）、0.825（0.765，0.891）、0.798（0.726，0.878）、0.882（0.800，0.972）和 0.807（0.732，0.889）。分层分析表明，对于年龄在 55 岁或以上的个体，影响更大。
肥胖指数与中国农村人口骨质疏松症风险呈负相关，尤其是在老年人中。
