Department of Oncology and Radiation Therapy, Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, 127473, Russia.
Biochemistry (Mosc). 2022 Jan;87(Suppl 1):S86-S47. doi: 10.1134/S0006297922140073.
In the article, the author examines the properties of Y-box-binding protein (YB-1) and expression of the YBX-1 gene in various malignant tumors and provides the data from her own prospective study in breast cancer patients. YB-1 is a member of the highly conserved family of cold shock proteins with multiple functions in the cytoplasm and cell nucleus. YB-1 is involved in embryogenesis; it ensures cell proliferation and protects cell from the action of various aggressive environmental factors. In adult organisms, YB-1 is involved in a variety of cellular functions that regulate malignant phenotype in several types of tumors. YB-1 is a molecular marker of tumor progression that can be used in clinical practice as both prognostic factor and a target for anticancer therapy. Our prospective clinical study showed that expression of YB-1 mRNA is an independent prognostic factor, as breast cancer patients expressing YB-1 have a lower disease-free survival rate, regardless of the tumor stage and biological subtype. We recommend determining the level of YB-1 mRNA expression as a prognostic test in breast cancer patients.
在这篇文章中，作者研究了 Y 盒结合蛋白（YB-1）的性质和 YBX-1 基因在各种恶性肿瘤中的表达，并提供了她在乳腺癌患者中的前瞻性研究数据。YB-1 是高度保守的冷休克蛋白家族的成员，在细胞质和细胞核中具有多种功能。YB-1 参与胚胎发生；它确保细胞增殖并保护细胞免受各种侵袭性环境因素的作用。在成年生物体中，YB-1 参与多种细胞功能，调节几种类型肿瘤的恶性表型。YB-1 是肿瘤进展的分子标志物，可在临床实践中用作预后因素和抗癌治疗的靶点。我们的前瞻性临床研究表明，YB-1 mRNA 的表达是独立的预后因素，因为表达 YB-1 的乳腺癌患者无论肿瘤分期和生物学亚型如何，无病生存率都较低。我们建议将 YB-1 mRNA 表达水平确定为乳腺癌患者的预后检测。
