College of Chemistry and Molecular Sciences, Wuhan University, 299 Bayi Road, Wuhan, Hubei Province, China.
School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
Org Biomol Chem. 2022 May 18;20(19):3980-3987. doi: 10.1039/d2ob00399f.
Three quaternary ammonium compounds (QACs), TPQA, T2PQA, and T3PQA, were synthesized and employed in antimicrobial tests against and . It was confirmed that they exhibit selective bacteriostasis against . The antibacterial activities of the compounds were evaluated determining their minimum inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) against using the 2,3,5-triphenyltetrazolium chloride (TTC) coloration method. Notably, T2PQA exhibited far better properties than TPQA and T3PQA, with the activity found to be dependent on the structure of the QA and the exposed hydrophobic groups. All three compounds showed promising potential for killing Gram-positive bacteria, efficiently guided by fluorescence imaging.
合成了三种季铵盐（QACs），TPQA、T2PQA 和 T3PQA，并将其用于对抗 和 的抗菌测试。结果证实，它们对 具有选择性抑菌作用。通过使用 2,3,5-三苯基氯化四氮唑（TTC）显色法，测定化合物对 的最小抑菌浓度（MIC）和最小杀菌浓度（MBC），评估了这些化合物的抗菌活性。值得注意的是，T2PQA 的性能明显优于 TPQA 和 T3PQA，其活性取决于 QA 的结构和暴露的疏水性基团。所有三种化合物都表现出了杀灭革兰氏阳性菌的潜力，荧光成像实验为其提供了有力的指导。
