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[运动通过脂质自噬调节脂质代谢及其分子机制]

[Exercise regulates lipid metabolism via lipophagy and its molecular mechanisms].

作者信息

Li Meng-Ying, Li Ling-Jie, Ma Chun-Wei, Gao Bing-Hong

机构信息

School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.

School of Physical Training, Shanghai University of Sport, Shanghai 200438, China.

出版信息

Sheng Li Xue Bao. 2022 Apr 25;74(2):309-319.

Abstract

Lipophagy is a kind of selective autophagy, which can selectively identify and degrade lipid droplets and plays an important role in regulating cellular lipid metabolism and maintaining intracellular lipid homeostasis. Exercise can induce lipophagy and it is also an effective means of reducing body fat. In this review, we summarized the relationship between exercise and lipophagy in the liver, pancreas, adipose tissue, and the possible molecular mechanisms to provide a new clue for the prevention and treatment of fatty liver, obesity and other related metabolic diseases by exercise.

摘要

脂质自噬是一种选择性自噬,它能够选择性地识别并降解脂滴,在调节细胞脂质代谢和维持细胞内脂质稳态方面发挥着重要作用。运动可以诱导脂质自噬,也是减少体脂的有效手段。在这篇综述中,我们总结了运动与肝脏、胰腺、脂肪组织中脂质自噬的关系以及可能的分子机制,为通过运动预防和治疗脂肪肝、肥胖症及其他相关代谢性疾病提供新线索。

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