[脂肪自噬在脂质代谢调控中的作用及分子机制]
[Role of lipophagy in the regulation of lipid metabolism and the molecular mechanism].
作者信息
Shi Linna, Wang Ke, Deng Yudi, Wang Yingna, Zhu Shuangling, Yang Xushan, Liao Wenzhen
机构信息
Department of Nutrition, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
School of Public Health, Southern Medical University, Guangzhou 510515, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2019 Jul 30;39(7):867-874. doi: 10.12122/j.issn.1673-4254.2019.07.19.
Recent studies have discovered a selective autophagy-lipophagy, which can selectively identify and degrade lipids and plays an important role in regulating cellular lipid metabolism and maintaining intracellular lipid homeostasis. The process of lipophagy can be directly or indirectly regulated by genes, enzymes, transcriptional regulators and other factors. This review examines the role of lipophagy in reducing liver lipid content, regulating pancreatic lipid metabolism, and regulating adipose tissue differentiation, and summarizes the findings of the molecules (Rab GTPase, enzymes, ion channels, transcription factors, small molecular substances) involved in the regulation of lipophagy, which points to new directions for the treatment of diseases caused by lipid accumulation.
最近的研究发现了一种选择性自噬——脂质自噬，它能够选择性地识别并降解脂质，在调节细胞脂质代谢和维持细胞内脂质稳态方面发挥着重要作用。脂质自噬过程可受到基因、酶、转录调节因子及其他因素的直接或间接调控。本文综述了脂质自噬在降低肝脏脂质含量、调节胰腺脂质代谢以及调节脂肪组织分化中的作用，并总结了参与脂质自噬调节的分子（Rab GTP酶、酶、离子通道、转录因子、小分子物质）的研究结果，为治疗由脂质蓄积引起的疾病指明了新方向。
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