García e Silva L, Pereira F
Med Cutan Ibero Lat Am. 1986;14(6):387-90.
Marked cellular atypia was detected in 4 out of 2,000 consecutive specimens of basal cell carcinoma. The lesions occurred on the exposed skin of the head of 4 male patients with ages between 49 and 71 years. Besides the general pattern of basal cell carcinoma and cellular atypia there were remarkable differences from lesion to lesion resulting in variable difficulties of differential diagnosis, not only with Bowen's disease (3 cases) but with Darier's metatypical epithelioma as well, either of the mixed or intermediate type (1 case each). As with the other cases reported in the literature, the presence of cell atypia did not correlate with a more aggressive clinical behaviour of the lesions.
在2000例连续的基底细胞癌标本中,有4例检测到明显的细胞异型性。这些病变发生在4例年龄在49至71岁之间男性患者头部的暴露皮肤上。除了基底细胞癌和细胞异型性的一般模式外,不同病变之间存在显著差异,导致鉴别诊断存在不同程度的困难,不仅与鲍恩病(3例)鉴别困难,与达里埃氏异型上皮瘤(混合型或中间型各1例)鉴别也有困难。与文献中报道的其他病例一样,细胞异型性的存在与病变更具侵袭性的临床行为无关。