鞘磷脂合成酶家族和磷脂酶 C。
Sphingomyelin Synthase Family and Phospholipase Cs.
机构信息
Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
出版信息
Adv Exp Med Biol. 2022;1372:77-86. doi: 10.1007/978-981-19-0394-6_7.
Abstract
The sphingomyelin synthase (SMS) gene family has three members: SMS1 and SMS2 have SM synthase activity, while SMS-related protein (SMSr) has no SM synthase activity but has ceramide phosphorylethanolamine (CPE) synthase activity in vitro. Recently, we found that SMS family members are a group of phospholipase Cs (PLC). SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC. SMS family members not only influence SM levels but also influence the levels of diacylglycerol (DAG), PC, PE, and glycosphingolipids, thus influencing cell functions. In this chapter, we will discuss the recent progress in the research field of SMS family and will focus on its impact on metabolic diseases.
摘要
鞘磷脂合酶（SMS）基因家族有三个成员：SMS1 和 SMS2 具有 SM 合酶活性，而 SMS 相关蛋白（SMSr）没有 SM 合酶活性，但具有体外神经酰胺磷酸乙醇胺（CPE）合酶活性。最近，我们发现 SMS 家族成员是一组磷酯酶 C（PLC）。SMS1 和 SMS2 是两种磷脂酰胆碱（PC）-PLC，而 SMSr 是一种磷脂酰乙醇胺（PE）-PLC。SMS 家族成员不仅影响 SM 水平，还影响二酰基甘油（DAG）、PC、PE 和糖脂的水平，从而影响细胞功能。在本章中，我们将讨论 SMS 家族研究领域的最新进展，并重点介绍其对代谢性疾病的影响。
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