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鞘磷脂和维生素D3摄入对兔脑的影响。

Effect of Sphingomyelin and Vitamin D3 Intake on the Rabbit Brain.

作者信息

Fiorani Federico, Quattrone Alda, Cataldi Samuela, Pellegrino Roberto Maria, Emiliani Carla, Arcuri Cataldo, Mirarchi Alessandra, Curone Giulio, Menchetti Laura, Beccari Tommaso, Floridi Claudia, Mandarano Martina, Brecchia Gabriele, Albi Elisabetta

机构信息

Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.

Department of Veterinary Medicine, University of Milan, 26900 Lodi, Italy.

出版信息

Int J Mol Sci. 2025 Apr 1;26(7):3269. doi: 10.3390/ijms26073269.

DOI:10.3390/ijms26073269
PMID:40244129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11989450/
Abstract

Sphingomyelin is a crucial molecule in the sphingolipid metabolic pathway, and its action is closely related to that of vitamin D3. Both molecules are recognized for their involvement in brain pathophysiology. In this study, the effect of a sphingomyelin + vitamin D3-enriched diet was investigated in rabbits. The results showed a strong immunopositive GFAP staining in the brain's white matter. Furthermore, a remodeling of the balance between glycero-phospholipids and ether-phospholipids was observed in the brain, along with an increase in ceramides and hexose ceramides, molecules relevant for the structure, function, and stability of myelin. Taken together, these findings provide clues as to how the combination sphingomyelin + vitamin D3 may play a vital role in normal brain physiology and could potentially be leveraged in the context of neurodegenerative diseases.

摘要

鞘磷脂是鞘脂代谢途径中的关键分子，其作用与维生素D3密切相关。这两种分子都因其参与脑病理生理学而受到认可。在本研究中，研究了富含鞘磷脂+维生素D3的饮食对兔子的影响。结果显示，大脑白质中胶质纤维酸性蛋白（GFAP）染色呈强免疫阳性。此外，在大脑中观察到甘油磷脂和醚磷脂之间的平衡发生重塑，同时神经酰胺和己糖神经酰胺增加，这些分子与髓鞘的结构、功能和稳定性相关。综上所述，这些发现为鞘磷脂+维生素D3的组合如何在正常脑生理学中发挥重要作用提供了线索，并有可能在神经退行性疾病的背景下加以利用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/c482c0ffa943/ijms-26-03269-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/0eb04c0c242e/ijms-26-03269-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/e6f96105d2c5/ijms-26-03269-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/a0d80cbc4a50/ijms-26-03269-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/81cda93bc8fb/ijms-26-03269-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/c482c0ffa943/ijms-26-03269-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/0eb04c0c242e/ijms-26-03269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/1a7692ab1222/ijms-26-03269-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/fd82a650ef1b/ijms-26-03269-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/e6f96105d2c5/ijms-26-03269-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/81cda93bc8fb/ijms-26-03269-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c86/11989450/c482c0ffa943/ijms-26-03269-g007.jpg

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