Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University.
Division of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center.
Acta Med Okayama. 2022 Apr;76(2):229-233. doi: 10.18926/AMO/63428.
We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy.
我们报告了一例 70 多岁的日本女性下颌骨骨肉瘤病例，该患者 p16 阳性。尽管肿瘤生长迅速，但患者对化疗反应良好，随后能够进行手术。头颈部骨肉瘤（HNOS）是一种非常罕见的癌症，尽管手术的重要性已被指出，但化疗的效果尚不清楚。手术切缘阴性和对化疗的反应已被报道为预后因素；另一项报告评估了 p16 蛋白免疫组化表达作为化疗反应预测因子的有效性。
