Bravo-Valenzuela Nathalie Jeanne, Peixoto Alberto Borges, Mattar Rosiane, Araujo Júnior Edward
Department of Pediatrics, Pediatric Cardiology, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Department of Obstetrics and Gynecology, Federal University of Triângulo Mineiro (UFTM), Uberaba, Brazil.
J Cardiovasc Imaging. 2022 Apr;30(2):125-134. doi: 10.4250/jcvi.2021.0170.
To assess the interventricular septum (IVS) volume of fetuses from pre-gestational diabetes mellitus (DM) pregnant women by 3-dimensional ultrasound using spatiotemporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL) methods.
This was a prospective cross-sectional study of 45 fetuses from pre-gestational DM and 45 fetuses from healthy pregnant women (controls). Only singleton pregnancies between 20 and 34 + 6 weeks of gestation were included. The fetal IVS volumes were obtained off-line using STIC and VOCAL methods. To analyze differences among variables, the Student's t-test and Mann-Whitney U test were used. The correlation among continuous variables was determine using Spearman's correlation test (r).
The median of fetal IVS volume was significantly higher in pre-gestational DM than in healthy pregnant women (0.3 cm vs. 0.2 cm, p = 0.032). A strong positive correlation was observed between fetal IVS volume and gestational age at the time of ultrasound examination (r = 0.75, R² = 0.48, p < 0.0001) and between fetal IVS volume and estimated fetal weight (r = 0.63, R² = 0.37, p < 0.0001). No significant correlation was noted between fetal IVS volume and glycated hemoglobin levels (r = -0.16, R² = 0.01, p = 0.540) in the pre-gestational DM pregnant women.
Significant differences were observed in fetal IVS volumes between pre-gestational and healthy mothers, with higher values in the fetuses of pre-gestational DM pregnant women.
采用时空图像相关（STIC）和虚拟器官计算机辅助分析（VOCAL）方法，通过三维超声评估孕前糖尿病（DM）孕妇胎儿的室间隔（IVS）容积。
这是一项前瞻性横断面研究，纳入45例孕前糖尿病孕妇的胎儿和45例健康孕妇（对照组）的胎儿。仅纳入妊娠20至34 + 6周的单胎妊娠。使用STIC和VOCAL方法离线获取胎儿IVS容积。为分析变量间差异，采用Student's t检验和Mann-Whitney U检验。使用Spearman相关检验（r）确定连续变量间的相关性。
孕前糖尿病孕妇胎儿IVS容积中位数显著高于健康孕妇（0.3 cm对0.2 cm，p = 0.032）。超声检查时胎儿IVS容积与孕周之间（r = 0.75，R² = 0.48，p < 0.0001）以及胎儿IVS容积与估计胎儿体重之间（r = 0.63，R² = 0.37，p < 0.0001）观察到强正相关。在孕前糖尿病孕妇中，胎儿IVS容积与糖化血红蛋白水平之间未观察到显著相关性（r = -0.16，R² = 0.01，p = 0.540）。
孕前糖尿病孕妇与健康孕妇的胎儿IVS容积存在显著差异，孕前糖尿病孕妇胎儿的IVS容积值更高。
