Jaliawala Huzaifa A, Parmar Miloni, Summers Katherine, Bernardo Roberto J
Division of Pulmonary, Critical Care and Sleep Medicine University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA.
Department of Internal Medicine University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA.
Pulm Circ. 2022 Mar 14;12(1):e12053. doi: 10.1002/pul2.12053. eCollection 2022 Jan.
The second hit hypothesis in pulmonary hypertension refers to the development of pulmonary vascular disease in individuals at risk, after an additional exposure or "hit" to factors with potential injury to the pulmonary circulation, such as drugs or toxins. We here present a case of severe pulmonary hypertension diagnosed during the third trimester of pregnancy, in a patient with familial history of pulmonary hypertension, found to have a heterozygous mutation in the gene, who also had chronic exposure to prescription amphetamines. We hypothesize that exposure to prescription amphetamines could act as a second hit of pulmonary vascular injury in individuals at risk of pulmonary vascular disease.
肺动脉高压中的二次打击假说指的是，有肺动脉高压风险的个体，在受到另外一种对肺循环有潜在损伤的因素（如药物或毒素）的暴露或“打击”后，发生肺血管疾病。我们在此报告一例在妊娠晚期诊断出严重肺动脉高压的病例，该患者有肺动脉高压家族史，基因检测发现杂合突变，且长期接触处方类苯丙胺。我们推测，接触处方类苯丙胺可能会成为有肺血管疾病风险个体肺血管损伤的二次打击因素。
