McIntyre N
Gut. 1978 Jun;19(6):526-30. doi: 10.1136/gut.19.6.526.
There are many changes in the plasma, lipids, and lipoproteins in patients with liver disease. They have proved difficult to study but our understanding of these changes has increased greatly during recent years. In obstructive jaundice hyperlipidaemia is a fairly constant finding and this appears to be due to the regurgitation of phospholipid from the obstructed biliary tree. The plasma lipids tend to fall with parenchymal liver disease. The composition of the lipoproteins depends on the activity of the plasma enzyme lecithin: cholesterol acyl transferase. When LCAT activity is high the individual lipoprotein fractions are normal. When it is reduced all of the lipoprotein fractions are affected but the pattern found with obstruction is quite different from that found with parenchymal disease. The changes in plasma lipoproteins appear to be associated with change in the lipid composition of cellular membranes and this may have important functional implications.
肝病患者的血浆、脂质和脂蛋白会发生许多变化。这些变化一直难以研究，但近年来我们对这些变化的了解有了很大增加。在梗阻性黄疸中，高脂血症是一个相当常见的发现，这似乎是由于磷脂从受阻胆管树反流所致。实质性肝病时血浆脂质往往会下降。脂蛋白的组成取决于血浆酶卵磷脂：胆固醇酰基转移酶的活性。当卵磷脂：胆固醇酰基转移酶活性高时，各个脂蛋白组分是正常的。当该活性降低时，所有脂蛋白组分都会受到影响，但梗阻时发现的模式与实质性疾病时发现的模式有很大不同。血浆脂蛋白的变化似乎与细胞膜脂质组成的变化有关，这可能具有重要的功能意义。
