Song Yu, Hu Chuting, Wang Zheng, Wang Lin
Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
iScience. 2024 Mar 27;27(5):109604. doi: 10.1016/j.isci.2024.109604. eCollection 2024 May 17.
Previous works have focused on enhancing the tensile properties, mechanical flexibility, biocompatibility, and biodegradability of wearable devices for real-time and continuous health management. Silk proteins, including silk fibroin (SF) and sericin, show great advantages in wearable devices due to their natural biodegradability, excellent biocompatibility, and low fabrication cost. Moreover, these silk proteins possess great potential for functionalization and are being explored as promising candidates for multifunctional wearable devices with sensory capabilities and therapeutic purposes. This review introduces current advancements in silk-based constituents used in the assembly of wearable sensors and adhesives for detecting essential physiological indicators, including metabolites in body fluids, body temperature, electrocardiogram (ECG), electromyogram (EMG), pulse, and respiration. SF and sericin play vital roles in addressing issues related to discomfort reduction, signal fidelity improvement, as well as facilitating medical treatment. These developments signify a transition from hospital-centered healthcare toward individual-centered health monitoring and on-demand therapeutic interventions.
以往的研究致力于增强可穿戴设备的拉伸性能、机械柔韧性、生物相容性和生物降解性，以实现实时、连续的健康管理。包括丝素蛋白（SF）和丝胶蛋白在内的丝蛋白，因其天然的生物降解性、优异的生物相容性和较低的制造成本，在可穿戴设备中展现出巨大优势。此外，这些丝蛋白具有很强的功能化潜力，正被探索作为具有传感能力和治疗用途的多功能可穿戴设备的有前景候选材料。本综述介绍了用于组装可穿戴传感器和粘合剂以检测基本生理指标（包括体液中的代谢物、体温、心电图（ECG）、肌电图（EMG）、脉搏和呼吸）的丝基成分的当前进展。丝素蛋白和丝胶蛋白在减轻不适、提高信号保真度以及促进医疗治疗等相关问题上发挥着至关重要的作用。这些进展标志着从以医院为中心的医疗保健向以个人为中心的健康监测和按需治疗干预的转变。
