Zhang Hui, Xu Dongyu, Zhang Yong, Li Minli, Chai Renjie
State Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Science and Technology Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
School of Biological Science and Medical Engineering Southeast University Nanjing China.
Smart Med. 2022 Dec 23;1(1):e20220011. doi: 10.1002/SMMD.20220011. eCollection 2022 Dec.
Silk fibroin hydrogels occupy an essential position in the biomedical field due to their remarkable biological properties, excellent mechanical properties, flexible processing properties, as well as abundant sources and low cost. Herein, we introduce the unique structures and physicochemical characteristics of silk fibroin, including mechanical properties, biocompatibility, and biodegradability. Then, various preparation strategies of silk fibroin hydrogels are summarized, which can be divided into physical cross-linking and chemical cross-linking. Emphatically, the applications of silk fibroin hydrogel biomaterials in various biomedical fields, including tissue engineering, drug delivery, and wearable sensors, are systematically summarized. At last, the challenges and future prospects of silk fibroin hydrogels in biomedical applications are discussed.
丝素蛋白水凝胶因其卓越的生物学特性、优异的力学性能、灵活的加工性能以及丰富的来源和低成本，在生物医学领域占据着重要地位。在此，我们介绍丝素蛋白的独特结构和物理化学特性，包括力学性能、生物相容性和生物降解性。然后，总结了丝素蛋白水凝胶的各种制备策略，可分为物理交联和化学交联。重点系统总结了丝素蛋白水凝胶生物材料在包括组织工程、药物递送和可穿戴传感器在内的各种生物医学领域的应用。最后，讨论了丝素蛋白水凝胶在生物医学应用中的挑战和未来前景。
