克雷布斯在细胞分化中起了作用。
Krebs takes a turn at cell differentiation.
机构信息
Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
出版信息
Cell Metab. 2022 May 3;34(5):658-660. doi: 10.1016/j.cmet.2022.04.005.
In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.
在最近一期的《自然》杂志上，阿诺德等人报告说，柠檬酸从三羧酸循环的氧化步骤中分离出来，并进入柠檬酸-苹果酸穿梭系统，这对小鼠胚胎干细胞分化是必不可少的。他们的发现强调了代谢调控在发育生物学中的关键作用。
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