School of Physical Education, Shandong University, Jinan 250000, China.
School of Physical Education and Training, Shanghai University of sport, Shanghai, China.
Exp Gerontol. 2022 Jul;164:111827. doi: 10.1016/j.exger.2022.111827. Epub 2022 May 1.
To systematically evaluate the effect of blood flow restriction (BFR) combined with low-intensity (LI) training on muscular strength and function of older adults.
Databases including PubMed, Web of Science, EBSCO host, Cochrane Library, CNKI, Wan Fang Data were searched to collect randomized controlled trials (RTCs) investigating the effects of BFR-LI training on muscular strength and function of older adults. The Cochrane bias risk assessment tool was applied to evaluate the methodological quality of the included studies, and acquired data were statistically analyzed using Stata 14.0 software. The retrieval period is from the establishment of the database to February 2022.
Eighteen RCTs were included, with a total sample size of 419 people. Meta-analysis shows that BFR-LI training significantly improves the lower limb muscle strength (SMD: 0.66, 95%CI: [0.41,0.91], p < 0.001), and muscle function in Timed Up and Go Test (SMD: 0.79, 95%CI: [0.07,1.51], p < 0.05), and 30 Second Sit to Stand Test (SMD: 0.77, 95%CI: [0.13-1.40], p < 0.05). Different condition of control group (β = 0.48, 95% CI: [-0.98,-0.50], p < 0.01) and exercise duration (β = 1.05, 95% CI:[0.00,0.09], p < 0.05) were significant moderators in subgroup and meta-regression analyses. The effects of BFR-LI on strength gain are greater than regular LI-training in combined with resistance training and walking training, but weaker than the effect of high-intensity (HI) training.
BFR-LI training can effectively improve the muscular strength and function of the lower limbs of older adults. However, due to the limitations in the quality of the included research (inappropriate research design, small sample size, etc.), issues such as pressure intensity and exercise risk still need to be confirmed by more standardized and high-quality studies.
系统评价血流限制（BFR）结合低强度（LI）训练对老年人肌肉力量和功能的影响。
检索PubMed、Web of Science、EBSCO 主机、Cochrane 图书馆、CNKI、万方数据，收集 BFR-LI 训练对老年人肌肉力量和功能影响的随机对照试验（RTCs）。采用 Cochrane 偏倚风险评估工具评估纳入研究的方法学质量，采用 Stata 14.0 软件对获得的数据进行统计学分析。检索时间为数据库建立至 2022 年 2 月。
纳入 18 项 RCT，共 419 例样本。Meta 分析结果显示，BFR-LI 训练可显著提高下肢肌肉力量[标准化均数差（SMD）：0.66，95%置信区间（CI）：（0.41，0.91），p<0.001]和 Timed Up and Go 测试中的肌肉功能[SMD：0.79，95%CI：（0.07，1.51），p<0.05]以及 30 秒坐立测试[SMD：0.77，95%CI：（0.13，1.40），p<0.05]。不同的对照组条件（β=0.48，95%CI：[-0.98，-0.50]，p<0.01）和运动持续时间（β=1.05，95%CI：[0.00，0.09]，p<0.05）是亚组和元回归分析中的显著调节因素。BFR-LI 对力量增益的影响大于结合抗阻训练和行走训练的常规 LI 训练，但弱于高强度（HI）训练。
BFR-LI 训练可有效提高老年人下肢肌肉力量和功能。但由于纳入研究的质量受限（研究设计不当、样本量小等），压力强度和运动风险等问题仍需更多标准化和高质量的研究来证实。
