Ata Fateen, Yousaf Zohaib, Sardar Sundus, Javed Saad, Iqbal Phool, Khamees Ibraheem, Malkawi Lujain Salahaldeen, Yassin Mohamed A
Department of Internal Medicine Hamad General Hospital, Hamad Medical Corporation Doha Qatar.
Department of Internal Medicine Allama Iqbal Medical College Lahore Pakistan.
Health Sci Rep. 2022 May 3;5(3):e450. doi: 10.1002/hsr2.450. eCollection 2022 May.
Sickle Cell Disease (SCD) is a global health issue in hematology with a progressively increasing prevalence. There are recent advances in the management of SCD, with new drugs being introduced. It is essential to analyze the genetic makeup of SCD regionally to anticipate the effectiveness of management modalities. This systematic review's main objectives are (a) to combine the existing knowledge of the genetic composition of SCD in the Arab population and (b) to analyze the various phenotypes of SCD prevalent in the Arab population.
We will perform a systematic review and search multiple electronic databases predefined search terms to identify eligible articles. Eligible studies should report findings on the genetic testing of Sickle Cell disease in the 22 Arab countries. Case reports, case series, observational studies with cross-sectional or prospective research design, case-control studies, and experimental studies will be included. Study quality will be independently evaluated by two reviewers using the statistical methodology and categories guided by the Cochrane Collaboration Handbook and PRISMA guidelines.
This review will explore and integrate the evidence available on the various genotypes and phenotypes of SCD in the Arab population. By acquiring and summarizing data about the genetic and phenotypic variants of the SCD patient population, this study will add to the knowledge and help find more precise treatments.
The protocol is registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42020218666).
镰状细胞病（SCD）是血液学领域的一个全球性健康问题，其患病率呈逐步上升趋势。SCD的管理方面有了新进展，新型药物不断推出。对SCD进行区域基因构成分析对于预测管理模式的有效性至关重要。本系统评价的主要目标是：（a）整合阿拉伯人群中SCD基因构成的现有知识；（b）分析阿拉伯人群中普遍存在的SCD的各种表型。
我们将进行系统评价，并在多个电子数据库中搜索预定义的检索词，以识别符合条件的文章。符合条件的研究应报告22个阿拉伯国家镰状细胞病基因检测的结果。将纳入病例报告、病例系列、采用横断面或前瞻性研究设计的观察性研究、病例对照研究和实验性研究。研究质量将由两名评审员根据Cochrane协作手册和PRISMA指南指导的统计方法和类别进行独立评估。
本综述将探索并整合阿拉伯人群中SCD各种基因型和表型的现有证据。通过获取和总结SCD患者群体的基因和表型变异数据，本研究将增加相关知识，并有助于找到更精确的治疗方法。
该方案已在国际前瞻性系统评价注册库（PROSPERO；注册号：CRD42020218666）注册。
