Nawaz Shaik Sarfaraz, Siddiqui Khalid, Mujammami Muhammad, Alotaibi Obeed, Alanazi Saud Sulaiman, Rafiullah Mohamed
Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Int J Gen Med. 2022 Apr 27;15:4433-4440. doi: 10.2147/IJGM.S354220. eCollection 2022.
Osteopontin (OPN) is a 44-kDa multifunctional protein and has a diverse role in biomineralization, tissue remodeling, and chronic inflammation. However, its role in type 2 diabetes (T2D) patients with microvascular complications is not clear. Therefore, the present study aimed to investigate the role of OPN in T2D patients with microvascular complications.
A total of 324 type 2 diabetes patients in the age group of 38-66 years were included in this study; 249 T2D patients were diagnosed with microvascular complications. OPN was measured using an enzyme-linked immunosorbent assay kit. Clinical data, such as age, gender, diabetes duration, systolic blood pressure, diastolic blood pressure, were measured. Correlation between OPN levels with different clinical parameters was evaluated.
In patients with microvascular complications, OPN levels were significantly higher than those without microvascular complications (p < 0.05). Moreover, OPN levels were positively associated with systolic blood pressure (SBP), C-reactive protein, and albumin creatinine ratio (ACR). Multiple linear regression analysis showed that OPN levels were independently associated with C-reactive protein (p < 0.045).
The findings in the present study showed that OPN level was more positively associated with C-reactive protein than that with glucose metabolism in patients with microvascular complications. Thus, OPN might serve as a marker in predicting vascular disease.
骨桥蛋白（OPN）是一种44 kDa的多功能蛋白，在生物矿化、组织重塑和慢性炎症中发挥多种作用。然而，其在患有微血管并发症的2型糖尿病（T2D）患者中的作用尚不清楚。因此，本研究旨在探讨OPN在患有微血管并发症的T2D患者中的作用。
本研究纳入了324例年龄在38 - 66岁的2型糖尿病患者；其中249例T2D患者被诊断患有微血管并发症。使用酶联免疫吸附测定试剂盒测量OPN。测量临床数据，如年龄、性别、糖尿病病程、收缩压、舒张压等。评估OPN水平与不同临床参数之间的相关性。
在患有微血管并发症的患者中，OPN水平显著高于无微血管并发症的患者（p < 0.05）。此外，OPN水平与收缩压（SBP）、C反应蛋白和白蛋白肌酐比值（ACR）呈正相关。多元线性回归分析表明，OPN水平与C反应蛋白独立相关（p < 0.045）。
本研究结果表明，在患有微血管并发症的患者中，OPN水平与C反应蛋白的正相关性高于与糖代谢的正相关性。因此，OPN可能作为预测血管疾病的标志物。
