Feutren G, Bach J F
Rev Med Interne. 1987 Jan-Feb;8(1):91-8. doi: 10.1016/s0248-8663(87)80114-5.
Cyclosporine is an 11 aminoacid cyclic peptide of fungal origin endowed with potent immunosuppressive activity. Unlike the conventional immunosuppressants, cyclosporine does not interfere with DNA metabolism, but it selectively and reversibly inhibits lymphocyte T-helper activation by inhibiting the production of interleukin-2 which plays a role in immune response development. Cyclosporine has little effect on lymphocytes B and does not modify the production of antibodies when it is in progress. The drug is effective in preventing spontaneous or autoantigen-induced auto-immune diseases in animals. The best studied models are experimental allergic encephalomyelitis, uveitis in the rat and spontaneous diabetes of BB rats. However, cyclosporine has no effect on diseases exclusively due to the pathogenic action of antibodies, such as spontaneous thyroiditis of the obese chicken. It is also possible to obtain a curative effect, this type of model being nearer to therapeutic conditions in humans than the previous models.
环孢素是一种源自真菌的11氨基酸环肽，具有强大的免疫抑制活性。与传统免疫抑制剂不同，环孢素不干扰DNA代谢，但它通过抑制在免疫反应发展中起作用的白细胞介素-2的产生，选择性且可逆地抑制淋巴细胞辅助性T细胞的活化。环孢素对B淋巴细胞影响很小，在其发挥作用时不改变抗体的产生。该药物在预防动物的自发性或自身抗原诱导的自身免疫性疾病方面有效。研究得最充分的模型是实验性变应性脑脊髓炎、大鼠葡萄膜炎和BB大鼠的自发性糖尿病。然而，环孢素对仅由抗体致病作用引起的疾病无效，如肥胖鸡的自发性甲状腺炎。也有可能获得治愈效果，这种模型比之前的模型更接近人类的治疗条件。
