Kapytau Dzmitry, Kapytau Andrei, Khrushch Inessa, Kudin Ludmila, Waszkiewicz Napoleon
Department of Psychiatry and Medical Psychology, Belarusian State Medical University, Minsk, Belarus.
Department of Clinical and Diagnostic Laboratory, Belarusian State Medical University, Minsk, Belarus.
Front Psychiatry. 2022 Apr 18;13:819154. doi: 10.3389/fpsyt.2022.819154. eCollection 2022.
In alcohol withdrawal syndrome (AWS), pathophysiological mechanisms cover acid-base disturbances that affect the clinical picture of this state. An earlier study found that oxygen therapy methods in combination with pharmacotherapy improved the cognitive state in persons suffering from AWS. As impairments in the acid-base state influence the general health, timely and effective correction of these acid-base disturbances could result in a potential improvement in the treatment of the alcohol withdrawal symptoms. Therefore, the aim of this study was to evaluate the effectiveness of non-compressed oxygen therapy (NOT) and hyperbaric oxygenation (HBO) in combination with standard drug therapy (SDT), based on the dynamics of the acid-base state (ABS) in blood during AWS. HBO is the use of oxygen under pressure, whereas NOT uses oxygen without pressure. A comparative assessment of the acid-base state biomarkers was made in 160 patients with a moderate alcohol withdrawal state (3 groups), namely, in patients who underwent SDT only (control group/CG; = 42) and two comparison groups who underwent SDT in combination with NOT (SG1 group; = 56) and HBO (SG2 group; = 62). The use of both oxygen therapy methods (i.e., NOT and HBO) in combination with SDT corrected the ABS in a shorter time and more effectively, which was due to the better restoration of the carbonate buffer system. Although we did not find proof that novel oxygen-related therapeutic procedures such as NOT and HBO in combination with SDT improved the alcohol withdrawal symptoms, it helped with the faster restoration of the acid-base state.
在酒精戒断综合征（AWS）中，病理生理机制包括影响该状态临床表现的酸碱平衡紊乱。一项早期研究发现，氧疗方法与药物治疗相结合可改善AWS患者的认知状态。由于酸碱状态的损害会影响整体健康，及时有效地纠正这些酸碱紊乱可能会潜在地改善酒精戒断症状的治疗效果。因此，本研究的目的是根据AWS期间血液中酸碱状态（ABS）的动态变化，评估非压缩氧疗法（NOT）和高压氧疗法（HBO）与标准药物治疗（SDT）联合使用的有效性。HBO是在压力下使用氧气，而NOT是在无压力下使用氧气。对160例中度酒精戒断状态的患者（3组）进行了酸碱状态生物标志物的比较评估，即仅接受SDT的患者（对照组/CG；n = 42）以及接受SDT联合NOT的两个比较组（SG1组；n = 56）和接受SDT联合HBO的组（SG2组；n = 62）。两种氧疗方法（即NOT和HBO）与SDT联合使用能在更短时间内更有效地纠正ABS，这是由于碳酸盐缓冲系统得到了更好的恢复。虽然我们没有找到证据表明NOT和HBO等与SDT联合使用的新型氧相关治疗程序能改善酒精戒断症状，但它有助于更快地恢复酸碱状态。
