Jiang Hai, Pu Yu, Li Zeng-Hui, Liu Wei, Deng Yan, Liang Rui, Zhang Xiao-Ming, Zuo Hou-Dong
Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Apr 27;15:1305-1319. doi: 10.2147/DMSO.S359330. eCollection 2022.
Osteoarthritis (OA) is the most common joint disease in elderly individuals and seriously affects quality of life. OA has often been thought to be caused by body weight load, but studies have increasingly shown that OA is an inflammation-mediated metabolic disease. The current existing evidence suggests that OA is associated with obesity-related chronic inflammation as well as abnormal lipid metabolism in obesity, such as fatty acids (FA) and triglycerides. Adiponectin, a cytokine secreted by adipose tissue, can affect the progression of OA by regulating obesity-related inflammatory factors. However, the specific molecular mechanism has not been fully elucidated. According to previous research, adiponectin can promote the metabolism of FA and triglycerides, which indicates that it is a potential protective factor for OA through many mechanisms. This article aims to review the mechanisms of chronic inflammation, FA and triglycerides in OA, as well as the potential mechanisms of adiponectin in regulating chronic inflammation and promoting FA and triglyceride metabolism. Therefore, adiponectin may have a protective effect on obesity-related OA, which could provide new insight into adiponectin and the related mechanisms in OA.
骨关节炎（OA）是老年人中最常见的关节疾病，严重影响生活质量。OA通常被认为是由体重负荷引起的，但研究越来越表明，OA是一种炎症介导的代谢性疾病。目前现有的证据表明，OA与肥胖相关的慢性炎症以及肥胖中的脂质代谢异常有关，如脂肪酸（FA）和甘油三酯。脂联素是一种由脂肪组织分泌的细胞因子，可通过调节肥胖相关的炎症因子来影响OA的进展。然而，具体的分子机制尚未完全阐明。根据以往的研究，脂联素可以促进FA和甘油三酯的代谢，这表明它通过多种机制是OA的潜在保护因子。本文旨在综述OA中慢性炎症、FA和甘油三酯的机制，以及脂联素在调节慢性炎症和促进FA及甘油三酯代谢方面的潜在机制。因此，脂联素可能对肥胖相关的OA具有保护作用，这可能为脂联素及其在OA中的相关机制提供新的见解。
