Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China.
Orthopedic Clinical Medical Research Center and Intelligent Orthopedic Industry Technology Center of Gansu Province, Lanzhou 730030, China.
Biomolecules. 2024 Feb 29;14(3):292. doi: 10.3390/biom14030292.
Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete. In recent years, transient receptor potential vanilloid (TRPV) channels have emerged as key players in OA pathogenesis. This review provides an in-depth exploration of the role of the TRPV pathway in OA, encompassing its involvement in pain perception, inflammation, and mechanotransduction. Furthermore, we discuss the latest research findings, potential therapeutic strategies, and future directions in the field, shedding light on the multifaceted nature of TRPV channels in OA.
骨关节炎（OA）是一种使人虚弱的关节疾病，影响着全球数以百万计的人。尽管它很普遍，但我们对其潜在机制的理解仍不完整。近年来，瞬时受体电位香草醛（TRPV）通道已成为 OA 发病机制中的关键因素。这篇综述深入探讨了 TRPV 途径在 OA 中的作用，包括其在疼痛感知、炎症和机械转导中的参与。此外，我们还讨论了该领域的最新研究结果、潜在的治疗策略和未来方向，揭示了 TRPV 通道在 OA 中的多方面性质。
