血清成纤维细胞生长因子21与冠状动脉疾病的严重程度或存在与否相关吗？
Is serum fibroblast growth factor 21 associated with the severity or presence of coronary artery disease?
作者信息
Nar Gokay, Cetin Sanlialp Sara, Nar Rukiye, Kilic Oguz, Furkan Ozen Mehmet, Gunver Guven, Ilyas Sevgican Cihan
机构信息
Pamukkale University, Faculty of Medicine, Department of Cardiology, Denizli, Turkey.
Servergazi State Hospital, Department of Cardiology, Denizli, Turkey.
出版信息
J Med Biochem. 2022 Apr 8;41(2):162-167. doi: 10.5937/jomb0-30191.
BACKGROUND
Recent studies have shown that increased circulating concentrations of fibroblast growth factor 21 (FGF21) are associated with obesity, metabolic disorder, and atherosclerosis. However the relationship between FGF21 and coronary artery disease (CAD) is controversial This study was planned to investigate the role of FGF21 in CAD development and CAD severity.
METHODS
Seventy-eight patients with stable angina pectoris (SAP) (lesion positive) and 40 control patients (lesion negative) with similar cardiovascular risk factors were included in the study. Serum FGF21 levels were measured by ELISA method. CAD severity was evaluated by using SYNTAX and GENSINI risk scores.
RESULTS
FGF21 concentrations were found significantly higher in the SAP group than in the control group. [101.18 ± 141.62 vs. 47.93 ± 58.74 pg/mL; p = 0.03], no correlation was found between the SYNTAX (r = 0.146 and p = 0.134) and GENSINI (r = 0.211 and p = 0.084) scores with serum FGF21 levels. There was a negative relationship between serum FGF21 and serum HDL-C levels in correlation analysis (r = - 0.272; p = 0.026).
CONCLUSIONS
The serum FGF21 levels are different between SAP and control patients. FGF21 is a marker for CAD diagnosis, but not for the evaluation of CAD severity.
背景
近期研究表明，循环中成纤维细胞生长因子21（FGF21）浓度升高与肥胖、代谢紊乱及动脉粥样硬化相关。然而，FGF21与冠状动脉疾病（CAD）之间的关系存在争议。本研究旨在探讨FGF21在CAD发生发展及严重程度中的作用。
方法
本研究纳入了78例稳定型心绞痛（SAP）患者（病变阳性）和40例具有相似心血管危险因素的对照患者（病变阴性）。采用酶联免疫吸附测定（ELISA）法检测血清FGF21水平。使用SYNTAX和GENSINI风险评分评估CAD严重程度。
结果
发现SAP组的FGF21浓度显著高于对照组。[101.18±141.62 vs. 47.93±58.74 pg/mL；p = 0.03]，SYNTAX评分（r = 0.146，p = 0.134）和GENSINI评分（r = 0.211，p = 0.084）与血清FGF21水平之间未发现相关性。相关性分析显示血清FGF21与血清高密度脂蛋白胆固醇（HDL-C）水平呈负相关（r = - 0.272；p = 0.026）。
结论
SAP患者与对照患者的血清FGF21水平不同。FGF21是CAD诊断的标志物，但不是评估CAD严重程度的标志物。
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