Zhu Yun, Yu Zhen, Xu Ronggui, Wang Beibei, Lou Yiqun, Zhang Na, Chen Ziyin
Xianju County Peoples Hospital, Department of Cardiovascular Medicine, Taizhou, China.
Jinan Central Hospital, Department of Centralized Dispensing of Intravenous Drugs, Jinan, China.
J Med Biochem. 2023 Jan 20;42(1):9-15. doi: 10.5937/jomb0-37847.
To explore the associations of serum high-sensitivity C-reactive protein (hs-CRP) and prealbumin (PAB) with the number of diseased coronary vessels, degree of stenosis and heart failure in patients with myocardial infarction (MI).
A total of 39 MI patients treated in the Cardiology were selected as the observation group, and another 41 patients with normal results of coronary angiography during the same period were selected as the control group. The general data of patients were recorded in detail, the content of serum hs-CRP and PAB in the peripheral blood was detected, and the number of diseased coronary vessels and the degree of stenosis were detected via coronary angiography.
Compared with those in control group, the blood pressure and heart rate significantly rose, the content of indexes related to the severity of MI were significantly increased, the content of hs-CRP was significantly increased, and the content of PAB was significantly decreased in observation group. Hs-CRP was positively correlated with the number of diseased coronary vessels, degree of stenosis and heart failure in patients, but PAB was negatively correlated with the above factors. The survival rate of MI patients with high content of hs-CRP was obviously lower than that of patients with low content of hsCRP.
Serum hs-CRP and PAB are closely associated with the number of diseased coronary vessels, degree of stenosis and heart failure in MI patients.
探讨血清高敏C反应蛋白（hs-CRP）和前白蛋白（PAB）与心肌梗死（MI）患者冠状动脉病变血管数量、狭窄程度及心力衰竭的关系。
选取心内科收治的39例MI患者作为观察组，另选取同期冠状动脉造影结果正常的41例患者作为对照组。详细记录患者的一般资料，检测外周血血清hs-CRP和PAB含量，并通过冠状动脉造影检测冠状动脉病变血管数量及狭窄程度。
与对照组相比，观察组患者血压、心率明显升高，与MI严重程度相关的指标含量显著增加，hs-CRP含量显著升高，PAB含量显著降低。hs-CRP与患者冠状动脉病变血管数量、狭窄程度及心力衰竭呈正相关，而PAB与上述因素呈负相关。hs-CRP含量高的MI患者生存率明显低于hs-CRP含量低的患者。
血清hs-CRP和PAB与MI患者冠状动脉病变血管数量、狭窄程度及心力衰竭密切相关。
