循环成纤维细胞生长因子 21 水平与急性心肌梗死患者炎症因子及冠状动脉狭窄程度的相关性。

Correlation of circulating fibroblast growth factor 21 levels with inflammatory factors and the degree of coronary artery stenosis in patients with acute myocardial infarction.

机构信息

Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.

Departments of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.

出版信息

Cytokine. 2024 Jun;178:156591. doi: 10.1016/j.cyto.2024.156591. Epub 2024 Mar 29.

DOI:10.1016/j.cyto.2024.156591

PMID:38554500

Abstract

BACKGROUND

Fibroblast growth factor 21 (FGF21) is a secreted protein that plays an important role in atherosclerosis and pathological cardiac remodeling. However, the correlation between FGF21 and the degree of coronary artery stenosis and its potential role in acute myocardial infarction (AMI) remain unclear. We examined whether changes in FGF21 levels in AMI correlate with the degree of coronary artery stenosis and the levels of inflammatory factors, and preliminarily investigated the effects of FGF21 on inflammatory factor levels and myocardial injury in rats with AMI.

METHODS

Serum levels of FGF21 and inflammatory factors in the AMI group and control group were measured, and the correlation between FGF21 and clinical indicators and inflammatory factors was analyzed. The effects of FGF21 on cardiac function and inflammatory response were evaluated through echocardiography and measurement of inflammatory factors.

RESULTS

Multivariate logistic regression analysis showed that neutrophil percentage (NEUT%, odds ratio [OR]: 1.232; 95 % confidence interval [CI]: 1.028-1.477; p = 0.024) and FGF21 levels (OR: 2.063; 95 % CI: 1.187-3.586; p = 0.01) had independent effects on AMI. Spearman's rank correlation test showed that FGF21 levels were positively correlated with leukocyte count, NEUT%, neutrophil count, neutrophil to lymphocyte ratio, C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), monocyte chemotactic protein-1 (MCP-1) and Gensini scores (p < 0.01), but negatively correlated with lymphocyte count (p < 0.01). FGF21 levels in myocardial tissues and serum levels of FGF21, IL-6, TNF-a, and MCP-1 were significantly higher in AMI rats than in the sham-operated group (p < 0.01). After overexpression of FGF21, serum levels of IL-6, TNF-a, and MCP-1 in rats were significantly decreased (p < 0.01), and cardiac function improved significantly.

CONCLUSIONS

FGF21 levels were independently associated with AMI and may be related to the severity of coronary artery stenosis. Overexpression of FGF21 reduced serum inflammatory factor levels and improved cardiac function in AMI rats.

摘要

背景

成纤维细胞生长因子 21（FGF21）是一种分泌蛋白，在动脉粥样硬化和病理性心脏重构中发挥重要作用。然而，FGF21 与冠状动脉狭窄程度的相关性及其在急性心肌梗死（AMI）中的潜在作用尚不清楚。我们研究了 AMI 患者中 FGF21 水平的变化是否与冠状动脉狭窄程度以及炎症因子水平相关，并初步探讨了 FGF21 对 AMI 大鼠炎症因子水平和心肌损伤的影响。

方法

检测 AMI 组和对照组患者血清中 FGF21 和炎症因子的水平，并分析 FGF21 与临床指标和炎症因子的相关性。通过超声心动图和炎症因子的测量评估 FGF21 对心脏功能和炎症反应的影响。

结果

多因素 logistic 回归分析显示，中性粒细胞百分比（NEUT%，比值比 [OR]：1.232；95%置信区间 [CI]：1.028-1.477；p=0.024）和 FGF21 水平（OR：2.063；95%CI：1.187-3.586；p=0.01）对 AMI 有独立影响。Spearman 秩相关检验显示，FGF21 水平与白细胞计数、NEUT%、中性粒细胞计数、中性粒细胞与淋巴细胞比值、C 反应蛋白、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、单核细胞趋化蛋白-1（MCP-1）和 Gensini 评分呈正相关（p<0.01），与淋巴细胞计数呈负相关（p<0.01）。AMI 大鼠心肌组织和血清中 FGF21、IL-6、TNF-a 和 MCP-1 水平明显高于假手术组（p<0.01）。过表达 FGF21 后，大鼠血清中 IL-6、TNF-a 和 MCP-1 水平明显降低（p<0.01），心脏功能明显改善。