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光化学控制治疗剂的光催化异构化。

Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization.

机构信息

Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Sciences, University of Geneva, 1211, Geneva, Switzerland.

出版信息

Angew Chem Int Ed Engl. 2022 Jul 11;61(28):e202203390. doi: 10.1002/anie.202203390. Epub 2022 May 20.

DOI:10.1002/anie.202203390
PMID:35510306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9400970/
Abstract

A Ru(bpy) Cl photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin A-4 (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.

摘要

一种 Ru(bpy)Cl 光催化剂被应用于一系列含有烯烃的药物的快速顺反异构化，包括在肿瘤学中有临床应用前景的 Combretastatin A-4（CA-4）和白藜芦醇衍生物，将它们的结构从无活性物质转化为有效的细胞毒性剂。我们证明了 CA-4 类似物 Res-3M 的选择性细胞内激活，以及它的强大的细胞毒性和对微管动力学的抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/cab613422c9b/ANIE-61-0-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/249426102372/ANIE-61-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/652cbe49b862/ANIE-61-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/970c02581e8b/ANIE-61-0-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/738a926dca50/ANIE-61-0-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/fbe2425609d0/ANIE-61-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/cab613422c9b/ANIE-61-0-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/249426102372/ANIE-61-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/652cbe49b862/ANIE-61-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/970c02581e8b/ANIE-61-0-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/738a926dca50/ANIE-61-0-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/fbe2425609d0/ANIE-61-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1891/9400970/cab613422c9b/ANIE-61-0-g007.jpg

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