Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Dingjiaqiao, Nanjing, China.
Department of Prevention and Health Care, Rizhao People's Hospital, Shandong Provincial, Rizhao, China.
Pathog Glob Health. 2022 Dec;116(8):467-476. doi: 10.1080/20477724.2022.2057722. Epub 2022 May 4.
The objectives of this study were to explore global epidemiological characteristics of leprosy, and to provide reference for the construction of prevention strategies for leprosy. Computer retrieval of the study on the epidemiology of leprosy from 2010 to 2020 in Web of Science, PubMed, and SCOPUS databases were summarized. The included studies were assessed for the quality of the AHRQ; the proportions of the study indices were meta-analyzed with Stata 16.0. A random effects model was adopted to merge categories, including sex, type, grade 2 deformity (G2D) and age group for meta-analysis. The subgroup analysis used region as a stratification factor to analyze whether there were differences in the indicators. The meta-analysis included 30 studies totaling 11,353 cases. The global pooled proportion of male to female subjects with leprosy was 63% (95% CI 59%, 66%) to 37% (95% CI 34%, 41%), respectively. The pooled multibacillary proportion and paucibacillary proportion were 69% (95% CI 62%, 76%) and 31% (95% CI 24%, 38%), respectively. The pooled grade 2 deformity (G2D) proportion was 22% (95% CI 15%, 30%). Among age groups, the pooled children proportion was 11% (95% CI 8%, 13%), and the pooled adult proportion was 89% (95% CI 87%, 92%). The subgroup analysis indicated that epidemiological indicators varied from country to country. This study suggested that disparities existed between sex, type, grade 2 deformity (G2D) and age group characteristics of leprosy from country to country.
本研究旨在探讨麻风病的全球流行病学特征，为麻风病防治策略的制定提供参考。计算机检索 2010 年至 2020 年 Web of Science、PubMed 和 SCOPUS 数据库中关于麻风病流行病学的研究，对纳入研究进行 AHRQ 质量评估，采用 Stata16.0 软件对研究指标比例进行荟萃分析。采用随机效应模型对性别、类型、二级畸形（G2D）和年龄组等类别进行合并分析。亚组分析采用地区作为分层因素，分析指标是否存在差异。该荟萃分析共纳入 30 项研究，总计 11353 例。全球麻风病患者中男女比例的汇总比例分别为 63%（95%CI59%，66%）和 37%（95%CI34%，41%）。汇总的多菌型和少菌型比例分别为 69%（95%CI62%，76%）和 31%（95%CI24%，38%）。汇总的二级畸形（G2D）比例为 22%（95%CI15%，30%）。在年龄组中，儿童的汇总比例为 11%（95%CI8%，13%），成人的汇总比例为 89%（95%CI87%，92%）。亚组分析表明，各国的流行病学指标存在差异。本研究表明，各国麻风病在性别、类型、二级畸形（G2D）和年龄组特征方面存在差异。
