Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
J Dermatol. 2022 Sep;49(9):912-915. doi: 10.1111/1346-8138.16420. Epub 2022 May 5.
The association between psoriasis and alopecia areata has not been thoroughly investigated. The objective of this study is to investigate the association of psoriasis with alopecia areata. An electronic search was conducted in August 2021. The analysis included studies that reported sufficient data on the prevalence, odds, or hazard of alopecia areata in patients with psoriasis or that of psoriasis in patients with alopecia areata. Meta-analysis using an inverse variance method was performed with a random-effects model, assuming inherent heterogeneity between the included studies. The subgroup analyses were performed according to the age group and study quality. A total of 27 studies were included. The pooled prevalence of alopecia areata among patients with psoriasis was 0.5% (95% confidence interval [CI], 0.3-0.7%). The pooled odds ratio of alopecia areata among patients with psoriasis was 2.71 (95% CI, 2.29-3.21), whereas the pooled prevalence of psoriasis among patients with alopecia areata was 2.5% (95% CI, 2.0-3.0%). Moreover, the pooled odds ratio of psoriasis among patients with alopecia areata was 3.52 (95% CI, 1.27-9.74). The association of psoriasis and alopecia areata remained in the subgroup analyses according to the age group and study quality. In conclusion, this study suggests a bidirectional association between psoriasis and alopecia areata. Clinical examinations may be necessary to determine the presence of comorbid alopecia areata in patients with psoriasis and vice versa.
银屑病与斑秃之间的关联尚未得到彻底研究。本研究旨在探讨银屑病与斑秃之间的关联。我们于 2021 年 8 月进行了电子检索。分析纳入了报告银屑病患者斑秃患病率、比值比或风险以及斑秃患者银屑病患病率的研究，且这些研究提供了足够的数据。采用随机效应模型的Inverse Variance 方法进行荟萃分析，假设纳入研究之间存在固有异质性。根据年龄组和研究质量进行亚组分析。共纳入 27 项研究。银屑病患者斑秃的总患病率为 0.5%（95%CI，0.3-0.7%）。银屑病患者斑秃的比值比为 2.71（95%CI，2.29-3.21），而斑秃患者银屑病的患病率为 2.5%（95%CI，2.0-3.0%）。此外，斑秃患者银屑病的比值比为 3.52（95%CI，1.27-9.74）。根据年龄组和研究质量进行的亚组分析表明，银屑病与斑秃之间存在关联。综上，本研究提示银屑病与斑秃之间存在双向关联。临床检查可能对于确定银屑病患者是否存在斑秃以及斑秃患者是否存在银屑病是必要的。
