J Drugs Dermatol. 2023 Jun 1;22(6):576-581. doi: 10.36849/JDD.7424.
A growing body of evidence suggests that several inflammatory skin diseases (ISDs) are associated with systemic inflammation and cardiovascular disease (CVDs).
We used the TriNetX analytics platform to conduct a retrospective, cross-sectional, single-center study in the Mount Sinai Health System network. Cases (all patients ≥18 years of age with a diagnosis of 1 of the 4 ISDs studied) were compared with matched controls (no history of any of these ISDs) to evaluate odds ratios for being diagnosed with CVD.
We identified a total of 70,090 patients with ISDs, including 35,160 patients with atopic dermatitis, 19,490 with psoriasis, 12,470 with rosacea, and 2,970 with alopecia areata, and 70,090 propensity score-matched controls without any of these ISDs. Patients with atopic dermatitis and psoriasis had significantly increased odds of all CVD diagnoses analyzed compared to controls (P<0.001 for all comparisons). Patients with rosacea had significantly increased odds of being diagnosed with all diseases of the circulatory system (P<0.001), hypertensive diseases (P<0.001), cerebrovascular diseases (P=0.037), and arterial disease (P<0.001) compared to controls. Patients with alopecia areata had increased odds for all diseases of the circulatory system (P<0.001), hypertensive diseases (P<0.001), and arterial disease (P<0.001). The prevalence of patients with elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels was significantly greater in all ISD groups compared to controls.
This study identified significant associations between ISDs and several CVD diagnoses. Furthermore, CRP and ESR were elevated in all ISD groups compared to controls. Pagan AD, Jung S, Caldas S, et al. Cross-sectional study of psoriasis, atopic dermatitis, rosacea, and alopecia areata suggests association with cardiovascular diseases. J Drugs Dermatol. 2023;22(6):576-581. doi:10.36849/JDD.7424.
越来越多的证据表明，几种炎症性皮肤病（ISD）与全身炎症和心血管疾病（CVD）有关。
我们使用 TriNetX 分析平台在西奈山卫生系统网络中进行了一项回顾性、横断面、单中心研究。病例组（所有年龄≥18 岁且诊断为研究的 4 种 ISD 之一的患者）与匹配对照组（无这些 ISD 病史）进行比较，以评估诊断为 CVD 的比值比。
我们共确定了 70090 例 ISD 患者，包括 35160 例特应性皮炎患者、19490 例银屑病患者、12470 例酒渣鼻患者和 2970 例斑秃患者，以及 70090 例无任何这些 ISD 的匹配倾向评分对照。与对照组相比，特应性皮炎和银屑病患者所有分析的 CVD 诊断的可能性显著增加（所有比较 P < 0.001）。与对照组相比，酒渣鼻患者被诊断为所有循环系统疾病（P < 0.001）、高血压疾病（P < 0.001）、脑血管疾病（P=0.037）和动脉疾病（P < 0.001）的可能性显著增加。斑秃患者所有循环系统疾病（P < 0.001）、高血压疾病（P < 0.001）和动脉疾病（P < 0.001）的可能性增加。与对照组相比，所有 ISD 组的 C 反应蛋白（CRP）和红细胞沉降率（ESR）水平升高的患者比例显著更高。
本研究确定了 ISD 与几种 CVD 诊断之间存在显著关联。此外，与对照组相比，所有 ISD 组的 CRP 和 ESR 均升高。
