Southwest Transplant Alliance, Dallas, Texas, USA.
Mid-America Transplant, St. Louis, Missouri, USA.
Am J Transplant. 2022 Oct;22(10):2302-2305. doi: 10.1111/ajt.17083. Epub 2022 May 18.
Donation after circulatory determination of death (DCDD) has increased organ donation rates in the US over the past decade within an established legal framework, which is consistent with and supports individual and family decisions regarding organ donation in the context of end-of-life care. A new application, controlled DCDD donation utilizing thoracoabdominal normothermic regional perfusion (NRP) protocols (cDCDD-NRP), provides the opportunity to maximize a donation decision by recovering additional organs for transplant, including the heart, and to limit the detrimental impact of warm ischemic time by perfusing organs in situ following the declaration of circulatory death. In this viewpoint, we narrate our rationale for why cDCDD-NRP is consistent within the existing legal framework for organ donation in the United States and recommend no changes to the Uniform Determination of Death Act.
在既定的法律框架下,美国在过去十年中通过循环判定死亡后的捐献(DCDD)提高了器官捐献率,这与个人和家庭在临终关怀背景下关于器官捐献的决定一致,并为其提供支持。一种新的应用,即利用胸腹部常温区域灌注(NRP)方案的控制性 DCDD 捐献(cDCDD-NRP),为最大化捐献决策提供了机会,可通过回收更多的器官进行移植,包括心脏,并通过在宣布循环死亡后原位灌注器官来限制热缺血时间的不利影响。在这篇观点文章中,我们阐述了为什么 cDCDD-NRP 与美国现有的器官捐献法律框架一致的基本原理,并建议不要修改《统一死亡判定法案》。