Interdisciplinary Research Center for Advanced Materials, King Fahd University of Petroleum & Minerals, Dhahran, 31261, Saudi Arabia.
Chem Rec. 2022 Jul;22(7):e202200053. doi: 10.1002/tcr.202200053. Epub 2022 May 5.
Supramolecules-based drug delivery has attracted significant recent research attention as it could enhance drug solubility, retention time, targeting, and stimuli responsiveness. Among the different supramolecules and assemblies, the macrocycles and the supramolecular hydrogels are the two important categories investigated to a greater extent. Here, we provide the most recent advancements in these categories. Under macrocycles, reports on drug delivery by cyclodextrins, cucurbiturils, calixarenes/pillararenes, crown ethers and porphyrins are detailed. The second category discusses the supramolecular hydrogels of macrocycles/polymers and low molecular weight gelators. The updated information provided could be helpful to advance R & D in this vital area.
基于超分子的药物递送最近引起了广泛的研究关注，因为它可以提高药物的溶解度、滞留时间、靶向性和刺激响应性。在不同的超分子和组装体中，大环和超分子水凝胶是两个被更广泛研究的重要类别。在这里，我们提供了这两个类别的最新进展。在大环中，详细介绍了环糊精、瓜环、杯芳烃/柱芳烃、冠醚和卟啉的药物传递报告。第二类讨论了大环/聚合物和低分子量凝胶剂的超分子水凝胶。提供的最新信息可能有助于推进这一重要领域的研发。
