Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054, Erlangen, Germany.
Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Neurol Sci. 2022 Aug;43(8):4953-4959. doi: 10.1007/s10072-022-06103-x. Epub 2022 May 5.
Restless legs syndrome (RLS) is known to be associated with multiple sclerosis (MS) and may be caused by MS lesions in specific cerebral brain regions. Applying a voxel-wise lesion analysis, we tried to identify the contribution of cerebral MS lesions to RLS.
In this retrospective study, we established a cohort of people with MS with documented RLS and controls of people with MS without RLS matched disease severity. Diagnosis of MS and RLS was based on the current guidelines. The MS lesions were analyzed on T2-weighted magnetic resonance imaging scans (1.5 or 3 T). After manual delineation, lesion maps were converted into stereotaxic space. We generated a lesion overlap and performed a Liebermeister test with 4000 permutations to compare the absence or presence of RLS voxel-wise between patients with and without lesions in a given voxel.
Forty of the patients with RLS and MS fulfilled the inclusion criteria. The voxel-wise analysis yielded associations between RLS and MS in the subcortex of the left gyrus precentralis.
Our voxel-wise analysis shows associations in the subcortex of the left gyrus precentralis. Thus, our data suggests that a dysfunction of the efferent motor system due to cerebral lesions may contribute to the pathophysiology of RLS in MS.
已知不安腿综合征（RLS）与多发性硬化症（MS）有关，并且可能是由特定大脑脑区的 MS 病变引起的。通过体素分析，我们试图确定脑 MS 病变对 RLS 的贡献。
在这项回顾性研究中，我们建立了一个有记录的 RLS 多发性硬化症患者队列和匹配疾病严重程度的无 RLS 多发性硬化症患者对照。MS 和 RLS 的诊断基于当前的指南。在 T2 加权磁共振成像扫描（1.5 或 3T）上分析 MS 病变。手动描绘后，病变图被转换为立体定向空间。我们生成了病变重叠，并使用 4000 次置换进行 Liebermeister 检验，以比较给定体素中存在或不存在病变的患者之间 RLS 体素的缺失。
40 名患有 RLS 和 MS 的患者符合纳入标准。体素分析显示 RLS 与左侧大脑前回皮质下的 MS 之间存在关联。
我们的体素分析显示左侧大脑前回皮质下存在关联。因此，我们的数据表明，由于脑病变导致的传出运动系统功能障碍可能有助于 MS 中 RLS 的病理生理学。
