Department of Neurology, Tokat, Turkey.
Eur Neurol. 2011;65(5):302-6. doi: 10.1159/000327315. Epub 2011 May 13.
Multiple sclerosis (MS) is a demyelinating neurodegenerative inflammatory autoimmune disease. Restless legs syndrome (RLS) is characterized as a strong urge to move the legs to stop abnormal sensations there. In this study, we aimed to investigate whether or not the increased RLS frequency seen in MS could be associated with depression and fatigue.
The study involved 98 patients with definite MS and 129 healthy volunteers. The Beck Depression Inventory and Fatigue Severity Scale were used to assess all participants. The patients and the healthy volunteers were examined for RLS according to the criteria of the International Restless Legs Syndrome Study Group.
When the factors related to RLS in MS were evaluated, there were significant relationships found among age, type of MS, pyramidal symptoms, intestinal and bladder symptoms, number of lesions in MR, depression, and fatigue. Risk factors for RLS were also seen more frequently in the MS group than in the healthy volunteers.
RLS was seen 2.55 times more frequently in patients with MS than in the control group. This was due to the existence of numerous factors rather than a single factor - including depression and fatigue.
多发性硬化症（MS）是一种脱髓鞘神经退行性炎症自身免疫性疾病。不宁腿综合征（RLS）的特征是强烈的移动腿部以停止那里的异常感觉。在这项研究中，我们旨在研究在 MS 中看到的 RLS 频率增加是否与抑郁和疲劳有关。
该研究纳入了 98 例明确诊断为 MS 的患者和 129 名健康志愿者。所有参与者均采用贝克抑郁量表和疲劳严重程度量表进行评估。根据国际不宁腿综合征研究组的标准，对患者和健康志愿者进行 RLS 检查。
当评估与 MS 中 RLS 相关的因素时，年龄、MS 类型、锥体症状、肠和膀胱症状、MR 中的病变数量、抑郁和疲劳之间存在显著关系。MS 组的 RLS 危险因素也比健康对照组更常见。
MS 患者的 RLS 发生率是对照组的 2.55 倍。这是由于存在许多因素，而不是单一因素 - 包括抑郁和疲劳。
