Department of Adult Neurology, Medical University of Gdansk, Gdansk, Poland.
Department of Clinical Neuroimmunology, Chair of Neurology, Poznan University School of Medicine, Poznan, Poland; Neuroimmunlogical Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Poznan, Poland.
Sleep Med Rev. 2015 Aug;22:15-22. doi: 10.1016/j.smrv.2014.10.002. Epub 2014 Oct 12.
Restless legs syndrome (RLS) is a sleep-related sensory-motor disorder characterized by an irresistible urge to move the legs accompanied by unpleasant sensations in the lower extremities. According to many recent studies patients with multiple sclerosis (MS) suffer frequently from symptoms of RLS. The prevalence of RLS in MS patients varies 13.3%-65.1%, which is higher than the prevalence of RLS in people of the same age in the general population. MS patients with RLS have higher scores in the Expanded Disability Status Scale compared to MS patients without RLS. Presence of RLS has a negative impact on sleep quality and fatigue of MS patients. Iron deficiency and chronic inflammation may be factors contributing to development of RLS in MS. The relationship between the course and treatment of MS and RLS requires further prospective studies.
不宁腿综合征（RLS）是一种与睡眠相关的感觉运动障碍，其特征是腿部不可抗拒地移动冲动，并伴有下肢不愉快的感觉。根据许多最近的研究，多发性硬化症（MS）患者经常出现 RLS 症状。MS 患者中 RLS 的患病率为 13.3%-65.1%，高于同年龄普通人群中 RLS 的患病率。与无 RLS 的 MS 患者相比，有 RLS 的 MS 患者在扩展残疾状况量表中的评分更高。RLS 的存在对 MS 患者的睡眠质量和疲劳有负面影响。铁缺乏和慢性炎症可能是导致 MS 中 RLS 发展的因素。MS 和 RLS 的病程和治疗之间的关系需要进一步的前瞻性研究。
