Karal'nik B V, Nurkina N M
Zh Mikrobiol Epidemiol Immunobiol. 1987 Jan(1):49-52.
In 2,436 fecal samples and 1,272 urinary samples taken from 633 patients with dysentery caused by S. flexneri, S. newcastle and S. sonnei, Shigella antigens were detected by means of the passive hemagglutination test with antibody diagnostic agents and the antibody neutralization test. The antigen-binding activity of shigellae in urine dynamically increased in the course of dysentery. The comparison of the parallel results of both serological tests made it possible to evaluate the dispersion of the released antigen: it dynamically increased in the course of the disease, this increase being particularly high in feces. The dispersion of Shigella antigens in urine was greater than in feces over the entire course of the disease. These regularities in the release of the antigens and especially the specific features of the serological tests determined the scheme of the serological diagnosis of dysentery by the indication of Shigella antigens.
从633例由福氏志贺菌、纽卡斯尔志贺菌和宋内志贺菌引起的痢疾患者中采集了2436份粪便样本和1272份尿液样本，采用抗体诊断试剂的被动血凝试验和抗体中和试验检测志贺菌抗原。在痢疾病程中，尿液中志贺菌的抗原结合活性呈动态增加。两种血清学检测平行结果的比较使得评估释放抗原的离散度成为可能：其在疾病过程中呈动态增加，在粪便中这种增加尤为明显。在疾病的整个过程中，尿液中志贺菌抗原的离散度大于粪便中的。这些抗原释放规律，尤其是血清学检测的特异性特征，决定了通过检测志贺菌抗原进行痢疾血清学诊断的方案。
