Kuz'mina L A, Vlasov G S, Egorova N B, Salov V F, Sergeeva G S
Zh Mikrobiol Epidemiol Immunobiol. 1987 Jan(1):59-63.
The data obtained in the experimental study of the humoral factors of local and systemic immunity, as well as the morphofunctional changes of internal organs, after multiple subcutaneous and aerosol immunization with the combined preparation of Proteus, Staphylococcus, Klebsiella pneumoniae and Escherichia coli antigens (preparation nC-4) are presented. The subcutaneous and aerosol administration of preparation nC-4 has been found to induce an increase in the levels of antibodies to all components of the preparation in the blood serum and in respiratory tract secretions. The introduction of the preparation through the respiratory tract resulted in an earlier intensive accumulation of specific antibodies and IgA in respiratory tract secretions. The results of the quantitative cytological study of respiratory tract secretions and the morphofunctional changes of the lymphoid tissue associated with the lungs are indicative of an important role played by cell-mediated immunity factors in the formation of local postvaccinal immunity.
本文呈现了在用变形杆菌、葡萄球菌、肺炎克雷伯菌和大肠杆菌抗原联合制剂（制剂nC - 4）进行多次皮下和气溶胶免疫后，局部和全身免疫体液因子的实验研究以及内脏器官形态功能变化所获得的数据。已发现皮下和气溶胶给予制剂nC - 4可导致血清和呼吸道分泌物中针对制剂所有成分的抗体水平升高。通过呼吸道给予该制剂会使呼吸道分泌物中特异性抗体和IgA更早地大量积累。呼吸道分泌物的定量细胞学研究结果以及与肺相关的淋巴组织的形态功能变化表明，细胞介导的免疫因子在局部疫苗接种后免疫的形成中发挥着重要作用。
