Egorova N B, Efremova V N, Kreĭnin L S, Kaverina K G, Levashov Iu N
Zh Mikrobiol Epidemiol Immunobiol. 1987 Mar(3):49-53.
The results of the trial of an immunostimulating preparation, consisting of Klebsiella pneumoniae, Proteus, Escherichia coli and Staphylococcus antigenic complexes, on 20 patients with acute pulmonary abscess and bronchiectasis are presented. The preparation was introduced subcutaneously in 5 injections. The preparation was found to have low reactogenicity, and in the course of immunotherapy the manifestations of systemic and local reactions became considerably less pronounced. Immunotherapy produced a good curative effect, objectively manifested by a decrease in coughing and in the amount of sputum gradually changing its character. After the fourth and fifth injections the patients no longer ejected purulent sputum. Fluoroscopic examination revealed a considerable decrease in the size of the pathological focus. The preparation stimulated immunological reactions, and immunization resulted in a considerable increase in the titer of antibodies to all components of the combined preparation, as well as in an increase in the number of functionally active T-lymphocytes, in the blood of the patients.
本文介绍了一种免疫刺激制剂的试验结果，该制剂由肺炎克雷伯菌、变形杆菌、大肠杆菌和葡萄球菌抗原复合物组成，受试对象为20例急性肺脓肿和支气管扩张患者。该制剂通过皮下注射，分5次给药。结果发现该制剂的反应原性较低，在免疫治疗过程中，全身和局部反应的表现明显减轻。免疫治疗产生了良好的疗效，客观表现为咳嗽减轻，痰液量逐渐减少，性状改变。在第4次和第5次注射后，患者不再咳出脓性痰。荧光镜检查显示病灶大小显著减小。该制剂刺激免疫反应，免疫接种导致患者血液中针对联合制剂所有成分的抗体滴度显著增加，以及功能活跃的T淋巴细胞数量增加。
