Volgareva G M, Sviridov V V
Zh Mikrobiol Epidemiol Immunobiol. 1987 Jan(1):90-3.
The literature data on the regularities of the manifestation of tumorigenic capacity in somatic hybrids, on the correlation of this sign with the features of the in vitro transformation of hybrid cells, on the chromosomal stability and taking capacity of hybridomas have been analyzed. The expediency of the inoculation of animals with hybridomas, made considerably earlier than required by the traditional scheme of obtaining monoclonal antibodies, with a view to the selection of tumorigenic hybridoma variants is suggested. The aims of the experimental work have been determined.
分析了关于体细胞杂种致瘤能力表现规律、该特征与杂种细胞体外转化特性的相关性、杂交瘤染色体稳定性和接纳能力的文献数据。建议在用传统方法获取单克隆抗体所需时间之前很久就用杂交瘤接种动物，以便筛选出致瘤性杂交瘤变体。确定了实验工作的目标。
