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具有独特特性的光开关探针，用于选择性荧光成像和长期追踪。

Photoswitchable probe with distinctive characteristics for selective fluorescence imaging and long-term tracing.

作者信息

Tu Zhenzhen, Zhang Qian, Xu Xiuxia, Wang Lianhui, Qian Yan, Huang Wei

机构信息

Key Laboratory for Organic Electronics & Information Displays, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 China

出版信息

RSC Adv. 2019 Feb 7;9(9):4812-4815. doi: 10.1039/c8ra10057h. eCollection 2019 Feb 5.

DOI:10.1039/c8ra10057h
PMID:35514639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9060663/
Abstract

A photo-switchable and high-contrast bio-imaging indicator 4,4'-(1,1')-(4,4'-(cyclopentene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))bis(methan-1-yl-1-ylidene)bis(azan-1-yl-1-ylidene)bis(2-(benzo[]thiazol-2-yl)phenol) (BMBT) has been demonstrated, by integrating photochromophore with excited-state intramolecular proton transfer (ESIPT) moiety. The ability of reversible emission switching enables arbitrarily selective labeling or concealing of cells simply by controlling light irradiation. Besides, when the emission was switched on, BMBT is demonstrated to exhibit unique characteristics of aggregation induced emission (AIE), providing a high on-off ratio for favorable bio-imaging. Thus, the non-labeling and easily-controlled selective imaging, as well as good biocompatibility indicates BMBT to be a favorable cell probe with great potentials for functional bio-imaging fluorophore.

摘要

一种可光开关且具有高对比度的生物成像指示剂4,4'-(1,1')-(4,4'-(环戊烯-1,2-二基)双(5-甲基噻吩-4,2-二基))双(甲烷-1-基-1-亚基)双(氮杂-1-基-1-亚基)双(2-(苯并[]噻唑-2-基)苯酚)(BMBT)已被证实，它是通过将光发色团与激发态分子内质子转移(ESIPT)部分相结合而实现的。可逆发射切换的能力使得只需通过控制光照就能任意选择性地标记或隐藏细胞。此外，当发射开启时，BMBT被证明具有聚集诱导发光(AIE)的独特特性，为良好的生物成像提供了高开关比。因此，这种非标记且易于控制的选择性成像以及良好的生物相容性表明BMBT是一种具有巨大潜力的功能性生物成像荧光团的良好细胞探针。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/466f0e35f34a/c8ra10057h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/9d8b2bd8874e/c8ra10057h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/4d5d79b0fc89/c8ra10057h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/153ec24adb47/c8ra10057h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/368c3245b66e/c8ra10057h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/466f0e35f34a/c8ra10057h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/9d8b2bd8874e/c8ra10057h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/4d5d79b0fc89/c8ra10057h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/153ec24adb47/c8ra10057h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/368c3245b66e/c8ra10057h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe03/9060663/466f0e35f34a/c8ra10057h-f4.jpg

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