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聚（乙二醇）刷 - 基于聚（乙烯基吡咯烷酮）的双亲水嵌段共聚物颗粒交联结晶α-环糊精域。

Poly(ethylene glycol) brush--poly(-vinylpyrrolidone)-based double hydrophilic block copolymer particles crosslinked crystalline α-cyclodextrin domains.

作者信息

Al Nakeeb Noah, Kochovski Zdravko, Li Tingting, Zhang Youjia, Lu Yan, Schmidt Bernhard V K J

机构信息

Max-Planck Institute of Colloids and Interfaces, Department of Colloid Chemistry Am Mühlenberg 1 14476 Potsdam Germany

Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie 14109 Berlin Germany.

出版信息

RSC Adv. 2019 Feb 8;9(9):4993-5001. doi: 10.1039/c8ra10672j. eCollection 2019 Feb 5.

DOI:10.1039/c8ra10672j
PMID:35514641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9060675/
Abstract

Self-assembly of block copolymers is a significant area of polymer science. The self-assembly of completely water-soluble block copolymers is of particular interest, albeit a challenging task. In the present work the self-assembly of a linear-brush architecture block copolymer, namely poly(-vinylpyrrolidone)--poly(oligoethylene glycol methacrylate) (PVP--POEGMA), in water is studied. Moreover, the assembled structures are crosslinked α-CD host/guest complexation in a supramolecular way. The crosslinking shifts the equilibrium toward aggregate formation without switching off the dynamic equilibrium of double hydrophilic block copolymer (DHBC). As a consequence, the self-assembly efficiency is improved without extinguishing the unique DHBC self-assembly behavior. In addition, decrosslinking could be induced without a change in concentration by adding a competing complexation agent for α-CD. The self-assembly behavior was followed by DLS measurement, while the presence of the particles could be observed cryo-TEM before and after crosslinking.

摘要

嵌段共聚物的自组装是高分子科学的一个重要领域。完全水溶性嵌段共聚物的自组装尤其令人关注，尽管这是一项具有挑战性的任务。在本工作中，研究了一种线性刷状结构嵌段共聚物，即聚（乙烯基吡咯烷酮）-聚（甲基丙烯酸寡聚乙二醇酯）（PVP-POEGMA）在水中的自组装。此外，组装结构通过超分子方式进行α-环糊精主客体络合交联。交联使平衡向聚集体形成方向移动，而不会中断双亲水嵌段共聚物（DHBC）的动态平衡。因此，在不消除独特的DHBC自组装行为的情况下提高了自组装效率。此外，通过添加α-环糊精的竞争络合剂，可以在浓度不变的情况下诱导解交联。通过动态光散射（DLS）测量跟踪自组装行为，而在交联前后可以通过低温透射电子显微镜（cryo-TEM）观察颗粒的存在情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/c6ff29384d0f/c8ra10672j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/486b878c4b7e/c8ra10672j-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/c8ee3e23ae3c/c8ra10672j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/7dc8fd49fffa/c8ra10672j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/f1849e2bbe71/c8ra10672j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/5d85b493a353/c8ra10672j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/c6ff29384d0f/c8ra10672j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/486b878c4b7e/c8ra10672j-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/c8ee3e23ae3c/c8ra10672j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/7dc8fd49fffa/c8ra10672j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/f1849e2bbe71/c8ra10672j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/5d85b493a353/c8ra10672j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86d2/9060675/c6ff29384d0f/c8ra10672j-f5.jpg

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