Toe Quezia K, Issitt Theo, Mahomed Abdul, Almaghlougth Fatma, Bahree Ishan, Sturge Charles, Hu Xueqi, Panselinas Ioannis, Burke-Gaffney Anne, Wort Stephen Jc, Quinlan Gregory John
Cario-Respiratory Interface, National Heart Lung Institute Imperial College London London UK.
Biology Department University of York York UK.
Pulm Circ. 2022 Apr 8;12(2):e12068. doi: 10.1002/pul2.12068. eCollection 2022 Apr.
Vascular endothelial cell dysfunction is reported in severe coronavirus disease 2019 disease, however, controversy exists regarding levels of angiotensin-converting enzyme 2 (ACE2) expression, a coreceptor for severe acute respiratory syndrome coronavirus 2, in these cells. We report ACE2 expression and positive regulation by both interleuki-6, hepcidin, and ferroportin knock-down in pulmonary artery endothelial cells with potential implications for viral infection.
据报道，在严重的2019冠状病毒病中存在血管内皮细胞功能障碍，然而，关于血管紧张素转换酶2（ACE2）的表达水平存在争议，ACE2是严重急性呼吸综合征冠状病毒2的一种共受体，存在于这些细胞中。我们报告了在肺动脉内皮细胞中ACE2的表达以及白细胞介素-6、铁调素和铁转运蛋白敲低对其的正向调节，这可能对病毒感染具有潜在影响。
