Riedel F
Acta Paediatr Scand. 1987 Jan;76(1):24-9. doi: 10.1111/j.1651-2227.1987.tb10409.x.
In order to evaluate long term effects of artificial ventilation, 27 children, who had been ventilated for more than five days in their neonatal period, were reinvestigated at school age. In 5 of them bronchopulmonary dysplasia had been diagnosed. Seven had more than 10 upper respiratory tract infections per year and 9 had recurrent obstructive airway disease. On pulmonary function testing (n = 23) 19% showed some airway obstruction, and in 43% bronchial hyperreactivity was found by bronchial provocation with histamine. There was a significant correlation (p less than 0.05) between bronchial hyperreactivity and the duration of neonatal ventilation. The degree of hyperreactivity (PC20, FEV1) also correlated with birth weight (p less than 0.005) and gestational age (p less than 0.02). It is concluded that prolonged neonatal ventilation might be followed by bronchial hyperreactivity, especially in the small and premature newborn.
为了评估人工通气的长期影响，对27名在新生儿期接受通气超过5天的儿童在学龄期进行了再次调查。其中5名被诊断为支气管肺发育不良。7名儿童每年有超过10次上呼吸道感染，9名有复发性阻塞性气道疾病。在肺功能测试中（n = 23），19%表现出一定程度的气道阻塞，43%通过组胺支气管激发试验发现有支气管高反应性。支气管高反应性与新生儿通气持续时间之间存在显著相关性（p < 0.05）。高反应性程度（PC20，FEV1）也与出生体重（p < 0.005）和胎龄（p < 0.02）相关。结论是，长时间的新生儿通气可能会导致支气管高反应性，尤其是在小样儿和早产儿中。
