低体重儿童及其母亲的气道反应性
Airway responsiveness in low birthweight children and their mothers.
作者信息
Chan K N, Noble-Jamieson C M, Elliman A, Bryan E M, Aber V R, Silverman M
机构信息
Paediatric Department, Royal Postgraduate Medical School, Hammersmith Hospital, London.
出版信息
Arch Dis Child. 1988 Aug;63(8):905-10. doi: 10.1136/adc.63.8.905.
In a prospective study on a cohort of 7 year old children of low birth weight (under 2000 g at birth), we observed an increased prevalence of airway responsiveness to histamine compared with a reference population of unselected, local schoolchildren. The airway responsiveness to histamine was significantly related to a history of asthma in first degree relatives (natural parents and siblings) in both groups of children, but not to that of the mothers. There was no increase in the prevalence of maternal asthma, a family history of asthma, or airway responsiveness in the mothers of low birthweight children. We were unable to find evidence to support the hypothesis that maternal smooth muscle irritability (uterine and airway) has a causative role in the premature labour in the mothers and in subsequent bronchial hyper-responsiveness in their prematurely born children.
在一项针对一组出生体重低（出生时低于2000克）的7岁儿童的前瞻性研究中，我们观察到与未经过挑选的当地学童参考人群相比，气道对组胺反应性的患病率有所增加。两组儿童气道对组胺的反应性均与一级亲属（亲生父母和兄弟姐妹）的哮喘病史显著相关，但与母亲的哮喘病史无关。低出生体重儿童的母亲中，哮喘患病率、哮喘家族史或气道反应性均未增加。我们未能找到证据支持以下假设，即母体平滑肌易激惹（子宫和气道）在母亲早产及其早产子女随后的支气管高反应性中起因果作用。
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