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基于四氢喹啉的手性卡宾前体及相关手性NHC-Au(i)配合物的合成

Syntheses of tetrahydroquinoline-based chiral carbene precursors and the related chiral NHC-Au(i) complex.

作者信息

Zhan Licheng, Zhang Gengtao, Wang Jiwei, Zhang Jun

机构信息

Key Laboratory for Advanced Materials, Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology 130 Meilong Road Shanghai 200237 China

出版信息

RSC Adv. 2020 Sep 23;10(58):35253-35256. doi: 10.1039/d0ra07271k. eCollection 2020 Sep 21.

DOI:10.1039/d0ra07271k
PMID:35515693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9056819/
Abstract

Four tetrahydroquinoline-based chiral carbene precursors were synthesized using unsymmetrical ,'-diarylformamidines and chiral 2-allyloxiranes as starting materials. A representative NHC-gold complex has been prepared and fully characterized, the crystal structure of which reveals an intramolecular Au⋯H-C(sp) interaction between Au(i) and the hydrogen atom of the isopropyl moiety in the -aryl group.

摘要

以不对称的N,N'-二芳基甲脒和手性2-烯丙基环氧乙烷为原料，合成了四种基于四氢喹啉的手性卡宾前体。制备并全面表征了一种代表性的NHC-金配合物，其晶体结构揭示了Au(i)与芳基中异丙基部分的氢原子之间存在分子内Au⋯H-C(sp)相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/bcd9bbbd9570/d0ra07271k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/70f3c8a3bc47/d0ra07271k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/059ee9861da3/d0ra07271k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/3eb5eaa3beec/d0ra07271k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/e1c79a05c90b/d0ra07271k-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/86d52eff773b/d0ra07271k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/bcd9bbbd9570/d0ra07271k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/70f3c8a3bc47/d0ra07271k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/059ee9861da3/d0ra07271k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/3eb5eaa3beec/d0ra07271k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/e1c79a05c90b/d0ra07271k-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/86d52eff773b/d0ra07271k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db8b/9056819/bcd9bbbd9570/d0ra07271k-f2.jpg

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