Mun Jonghwan, Mok Jee Won, Jeong Sanghoon, Cho Seonghwi, Joo Choun-Ki, Hahn Sei Kwang
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH) 77 Cheongam-ro, Nam-gu Pohang Gyeongbuk 37673 Korea
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, Collage of Medicine, The Catholic University of Korea 505, Banpo-dong Seocho-gu Seoul 06591 Korea
RSC Adv. 2019 May 28;9(29):16578-16585. doi: 10.1039/c9ra02858g. eCollection 2019 May 24.
A contact lens is an attractive tool for the delivery of ophthalmic drugs, but it has several issues such as the burst release of drugs and the limited drug loading capacity. To overcome these limitations, we developed a cholesterol-hyaluronate (C-HA) micelle-embedded contact lens for efficient hydrophobic drug loading and long-term controlled drug delivery. The contact lens was fabricated photopolymerization of hydroxyethyl methacrylate (HEMA) using ethylene glycol dimethacrylate (EGDMA) as a cross-linker. The C-HA micelle-loaded contact lens showed statistically significant improvement in wettability and mechanical strength, maintaining the optical transmittance. drug release tests revealed the controlled delivery of cyclosporine for more than 12 days. Furthermore, the Schirmer tear test, corneal fluorescein staining, and MMP9 fluorescein analysis confirmed its therapeutic effect on dry eye syndrome in disease model rabbits.
隐形眼镜是一种用于眼部药物递送的有吸引力的工具，但它存在一些问题，如药物的突释和有限的载药量。为了克服这些限制，我们开发了一种嵌入胆固醇-透明质酸（C-HA）胶束的隐形眼镜，用于高效的疏水药物负载和长期的药物控释。该隐形眼镜是通过使用乙二醇二甲基丙烯酸酯（EGDMA）作为交联剂对甲基丙烯酸羟乙酯（HEMA）进行光聚合制备的。负载C-HA胶束的隐形眼镜在润湿性和机械强度方面有统计学上的显著改善，同时保持了透光率。药物释放测试显示环孢素的控释超过12天。此外，泪液分泌试验、角膜荧光素染色和基质金属蛋白酶9荧光分析证实了其对疾病模型兔干眼症的治疗效果。
