Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada; Institute of Biomaterials and Biomedical Engineering, 164 College Street, Toronto, ON M5S 3G9, Canada.
Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada; Institute of Biomaterials and Biomedical Engineering, 164 College Street, Toronto, ON M5S 3G9, Canada.
J Control Release. 2015 Dec 10;219:652-668. doi: 10.1016/j.jconrel.2015.09.065. Epub 2015 Oct 3.
Age-related ocular diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and glaucoma, result in life-long functional deficits and enormous global health care costs. As the worldwide population ages, vision loss has become a major concern for both economic and human health reasons. Due to recent research into biomaterials and nanotechnology major advances have been gained in the field of ocular delivery. This review provides a summary and discussion of the most recent strategies employed for the delivery of both drugs and cells to the eye to treat a variety of age-related diseases. It emphasizes the current challenges and limitations to ocular delivery and how the use of innovative materials can overcome these issues and ultimately provide treatment for age-related degeneration and regeneration of lost tissues. This review also provides critical considerations and an outlook for future studies in the field of ophthalmic delivery.
与年龄相关的眼部疾病，如年龄相关性黄斑变性（AMD）、糖尿病视网膜病变和青光眼，会导致终身的功能缺陷和巨大的全球医疗保健费用。随着全球人口老龄化，视力丧失已成为经济和人类健康的主要关注点。由于最近对生物材料和纳米技术的研究，眼用给药领域取得了重大进展。本文综述了最近用于向眼部递药和递细胞以治疗各种与年龄相关疾病的策略，对其进行了总结和讨论。本文强调了眼用给药目前面临的挑战和局限性，以及创新材料的使用如何克服这些问题，最终为与年龄相关的组织退化和再生提供治疗。本文还对眼科给药领域未来的研究提供了关键的考虑因素和展望。
