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-丁烷亚磺酰胺在氮杂环 亚磺亚胺合成中的应用。

Applications of -butanesulfinamide in the synthesis of N-heterocycles sulfinimines.

作者信息

Philip Rose Mary, Radhika Sankaran, Saranya P V, Anilkumar Gopinathan

机构信息

School of Chemical Sciences, Mahatma Gandhi University Priyadarsini Hills P O Kottayam Kerala 686560 India

Advanced Molecular Materials Research Centre (AMMRC), Mahatma Gandhi University Priyadarsini Hills P O Kottayam Kerala 686560 India.

出版信息

RSC Adv. 2020 Nov 23;10(69):42441-42456. doi: 10.1039/d0ra08819f. eCollection 2020 Nov 17.

DOI:10.1039/d0ra08819f
PMID:35516764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9058287/
Abstract

Chiral sulfinamides are among the best known chiral auxiliaries in the stereoselective synthesis of amines and their derivatives. The most extensively used enantiopure -butanesulfinamide emerged as the gold standard among many others over the last two decades. The present review attempts to provide an overview of -butanesulfinamide mediated asymmetric N-heterocycle synthesis sulfinimines and covers literature from 2010-2020. This methodology offers general access to structurally diverse piperidines, pyrrolidines, azetidines, and their fused derivatives that represent the structural motif of many natural products and therapeutically applicable compounds.

摘要

手性亚磺酰胺是胺及其衍生物立体选择性合成中最著名的手性助剂之一。在过去二十年中，使用最为广泛的对映体纯的丁烷亚磺酰胺成为众多其他手性助剂中的金标准。本综述试图概述丁烷亚磺酰胺介导的不对称N-杂环合成——亚磺酰亚胺，并涵盖2010年至2020年的文献。该方法为结构多样的哌啶、吡咯烷、氮杂环丁烷及其稠合衍生物提供了通用的合成途径，这些衍生物代表了许多天然产物和具有治疗应用价值的化合物的结构基序。

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