Draelos Zoe Diana
Dermatology Consulting Services, PLLC, High Point, NC, USA.
Psoriasis (Auckl). 2022 Apr 29;12:63-71. doi: 10.2147/PTT.S360448. eCollection 2022.
This study examined the efficacy and tolerability of a once-daily regimen of a 3% salicylic acid treatment gel containing turmeric and a low concentration of salicylic acid plus shea butter exfoliating moisturizer when used as monotherapy or in as an adjunct to other Rx psoriasis medications.
This single-site 12-week study enrolled 20 subjects >18 years of age with mild-to-moderate psoriasis involving <10% body surface area. Assessments were performed at baseline and Weeks 4, 8, and 12 using a 5-point scale (0 = none to 4 = severe). The investigator-assessed efficacy (changes from baseline for erythema, desquamation, induration, and overall global assessment [IGA]) and tolerability (irritation and edema). Study subjects assessed efficacy parameters of redness, scaling, and overall skin problems along with tolerability parameters of stinging, burning, itching, and irritation. Subjects applied the turmeric and salicylic acid treatment gel along with a moisturizer once daily to all affected areas.
Half (50%) of the subjects were using concomitant Rx psoriasis treatments, while the other 50% received the study psoriasis treatment regimen as monotherapy. Investigator assessments of erythema, desquamation, induration, and IGA scores showed significant reductions from baseline ( ≤ 0.021) at Weeks 4, 8, and 12. At Week 12, these reductions reached 48%, 46%, 51%, and 48%, for these parameters, respectively. The investigator observed no irritation or edema at any time point. Subject assessments of redness, scaling, and overall improvement demonstrated significant reductions in 8 of 9 assessments ( ≤ 0.037). The subjects reported mild irritation at Weeks 4, 8, and 12. No treatment compliance issues or adverse events related to study product occurred during the study.
A once-daily over-the-counter (OTC) turmeric/salicylic acid gel followed by a shea butter/salicylic acid exfoliating moisturizer demonstrated excellent tolerability and efficacy in plaque-type psoriasis after 12 weeks of once-daily use.
本研究考察了一种每日一次的治疗凝胶（含姜黄、低浓度水杨酸和乳木果油去角质保湿剂的3%水杨酸治疗凝胶）作为单一疗法或辅助其他银屑病处方药时的疗效和耐受性。
这项单中心为期12周的研究招募了20名年龄大于18岁、患有轻度至中度银屑病且体表面积受累小于10%的受试者。在基线期以及第4、8和12周使用5分制量表（0 = 无至4 = 严重）进行评估。由研究者评估疗效（红斑、脱屑、硬结和整体综合评估[IGA]相对于基线的变化）和耐受性（刺激和水肿）。研究受试者评估发红、脱屑和整体皮肤问题的疗效参数以及刺痛、灼痛、瘙痒和刺激的耐受性参数。受试者每天一次将姜黄和水杨酸治疗凝胶与保湿剂涂抹于所有受累部位。
一半（50%）的受试者同时使用银屑病处方药治疗，而另外50%接受研究的银屑病治疗方案作为单一疗法。研究者对红斑、脱屑、硬结和IGA评分的评估显示，在第4、8和12周相对于基线有显著降低（≤0.021）。在第12周，这些参数的降低分别达到48%、46%、51%和48%。研究者在任何时间点均未观察到刺激或水肿。受试者对发红、脱屑和整体改善的评估显示，9项评估中有8项有显著降低（≤0.037）。受试者在第4、8和12周报告有轻度刺激。研究期间未出现与研究产品相关的治疗依从性问题或不良事件。
每日一次使用非处方（OTC）姜黄/水杨酸凝胶，随后使用乳木果油/水杨酸去角质保湿剂，在每日一次使用12周后，对斑块型银屑病显示出优异的耐受性和疗效。
