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假海葵毒素A-D，一种来自内生真菌的七肽化合物

Pseudonectrins A-D, heptaketides from an endophytic fungus .

作者信息

Fu Peinan, Zhou Tingnan, Ren Fengxia, Zhu Shuaiming, Zhang Yang, Zhuang Wenying, Che Yongsheng

机构信息

School of Medicine and Life Sciences, Nanjing University of Chinese Medicine Nanjing 210023 People's Republic of China.

State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology Beijing 100850 People's Republic of China

出版信息

RSC Adv. 2019 Apr 17;9(21):12146-12152. doi: 10.1039/c9ra01787a. eCollection 2019 Apr 12.

DOI:10.1039/c9ra01787a
PMID:35517032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9063488/
Abstract

Four new heptaketides, pseudonectrins A-D (1-4), and four known compounds (5-8) were isolated from cultures of an endophytic fungus . Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1-3 and 4 were assigned by electronic circular dichroism calculations and the modified Mosher method, respectively. Compound 1-3 showed moderate cytotoxicity, with IC values of 11.6-41.2 μM.

摘要

从一种内生真菌的培养物中分离出了四种新的七肽，即假蜜环菌素A-D（1-4）和四种已知化合物（5-8）。它们的结构主要通过核磁共振实验得以阐明。1-3和4的绝对构型分别通过电子圆二色性计算和改良的莫舍尔方法确定。化合物1-3表现出中等的细胞毒性，IC值为11.6-41.2μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/f6ca0ef044ee/c9ra01787a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/d8267ff3e347/c9ra01787a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/60422a649898/c9ra01787a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/863f504925b4/c9ra01787a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/826b97e9e08b/c9ra01787a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/8f2766826740/c9ra01787a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/f6ca0ef044ee/c9ra01787a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/d8267ff3e347/c9ra01787a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/60422a649898/c9ra01787a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/863f504925b4/c9ra01787a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/826b97e9e08b/c9ra01787a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/8f2766826740/c9ra01787a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82d/9063488/f6ca0ef044ee/c9ra01787a-f6.jpg

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本文引用的文献

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从巴西苏木（Caesalpinia echinata）中分离出的内生真菌拟毛壳菌（Nectria pseudotrichia）的杀利什曼原虫化合物。
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